Clinical Focus ›› 2021, Vol. 36 ›› Issue (1): 5-7.doi: 10.3969/j.issn.1004-583X.2021.01.001

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Systematic review on the efficacy of dual-energy CT and ultrasound in the diagnosis of gout

Lyu Yixuan1, Lu Zhanfei2, Sun Nianzhe1, Li Fuhan2, Liu Rong3()   

  1. 1. The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
    2. The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China
    3. Department of Geriatrics, the First Hospital of Lanzhou University, Lanzhou 730000, China
  • Received:2020-08-20 Online:2021-01-20 Published:2021-01-16
  • Contact: Liu Rong E-mail:liur15@lzu.edu.cn

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Abstract:

Objective To assess the efficacy of ultrasound and dual-energy CT (DECT) in the diagnosis of gout. Methods PubMed, Embase, Cochrane Library, CNKI, Wanfang Data and CBM database were searched for the studies about diagnostic accuracy of DECT and ultrasound in gout. The deadline for the search was June 30, 2018. Four researchers screened and extracted data based on the inclusion and exclusion criteria, with two people in one group. The QUADAS-2 entry was used to evaluate the methodological quality of the included studies. The heterogeneity test Meta-analysis were conducted on sensitivity (SEN), specificity (SPE), positive likelihood ratio (+LR) and negative likelihood ratio (-LR) with the use of Meta-Disc 1.4. The summary receiver operating characteristics (SROC) curve was plotted, and the area under the curve (AUC) was calculated. Results DECT was included in 22 studies involving 1 999 subjects, and ultrasound was included in 10 studies involving 941 subjects. The SEN, SPE and AUC of in the combined studies including DECT were 0.91(CI 95%[0.90, 0.93]), 0.92(CI 95%[0.90, 0.94]) and 0.9725, respectively, and those in the combined studies including ultrasound were 0.77 (CI 0.95%[0.73, 0.80]), 0.88(CI 0.95%[0.85, 0.91]) and 0.8993. Conclusion DECT has a higher diagnostic efficacy than ultrasound.

Key words: gout, ultrasonography, radiography, dual-energy scanned projection, diagnostic test, systematic review

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