Abstract: ObjectiveTo  evaluate the value of interferon gamma(IFNγ) measurements in the diagnosis of tuberculous pleural effusion. MethodsA systematic review was conducted in  CNKI， WANFANG DATA， Pubmed， Cochrane library， CBM and EMbase to identify studies on the evaluation of the diagnosis accuracy of  IFNγ for tuberculous pleurisy effusion from inception to July 2016. Metaanalysis was performed using MetaDisc software provided by Cochrane Collaboration， and the heterogeneity was evaluated. Finally， 27 papers were included. ResultsThe summary estimates for IFNγ in the diagnosis of tuberculous pleurisy effusion were sensitivity (SEN) 0.91(95%CI  0.890.93)， specidicity 0.96(95%CI=0.950.97)， positive likelihood ratio (+LR) 20.26(95%CI  13.1631.19)， negative likelihood ratio (-LR) 0.1(95%CI  0.080.14)，diagnostic odds ratio 250.8(95%CI  138.7453.41) and the area under the SROC was 0.9816. ConclusionIFN γ  in pleural effusion plays a valuable role in the diagnosis of tuberculous pleurisy effusion.

Key words: pleural effusion, tuberculosis, interferongamma, diagnosis, meta analysis