Abstract: Objective  To investigate the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) on thyroid hormone function. Methods  400 hospitalized patients of West China Hospital of Sichuan University with sleep breathing monitoring and thyroid function examination were enrolled from January 2015 to February 2016. The differences in gender， age， body mass index (BMI)， hypothyroidism， diabetes or hypertension， thyroid hormone levels (TSH， FT3， FT4) and thyroid associated antibodies (TgAb， TPOAb) were compared. The clinical data as well as the thyroid hormones and related antibodies were compared between the nonOSAHS and mild to severe OSAHS groups. The relationship between OSAHS and thyroid hormone levels was analyzed using binary Logistic regression analysis.Results  The proportion of male， age， BMI， combined diabetes or hypertension in the OSAHS group were higher than those in the non OSAHS group (P<0.01). The level of FT3 in the severe OSAHS group was slightly higher than that of the non OSAHS group and the mild OSAHS group (P<0.05). The positive rate of TPOAb in non OSAHS group was higher than that in group OSAHS (P=0.049). The binary Logistic regression analysis showed that OSAHS was not related to the thyroid function. Conclusion  OSAHS may have no effect on thyroid function.

Key words: sleep apnea, obstructive；hypothyroidism