Abstract: Objective  To assess the efficacy and safety of  Cyclosporine A(CsA) combined androgen and androgen alone in the treatment of  Aplastic Anemia (AA) with Chinese patients. Methods  Randomized controlled trails (RCT) of CsA for AA were collected from CNKI, WANFANG, and VIP. Other relevant hematological journals were also hand searched. The methodological quality of included studies was evaluated, and data analyses were performed with the software StataSE 12.0. Results  A total of 50 RCT with 3099 patients were included.The metaanalysis showed that,as for the total effective rate and complete remission rate, significant differences were noted between CsA+ androgen and androgen alone, ［total effective rate: RR and 95%CI were 1.37(1.31 to 1.43); complete remission rate: RR and 95%CI were 1.87(1.62 to 2.15)］. Conclusion  According to the domestic evidence, treatment with CsA combined androgen for AA may improve the clinical effectiveness,compared with androgen alone.

Key words: anemia, , aplastic;cyclosporine A, androgen, metaanalysis