Abstract: Objective  Growing evidence suggests that platelets play an  important role in the pathogenesis of acute respiratory distress syndrome(ARDS).  Previous basic studies have also confirmed that platelet inhibitor  aspirin  plays an important role in the occurrence and progression of  ARDS. This study aims to  metaanalyze  whether aspirin can reduce  the incidence of ARDS  in patients. Methods  A comprehensive search was conducted on PubMed, EMbase, Cochrane, WANFANG database and CNKI from 2011 to 2016 for the literature on the effect of aspirin on the incidence of ARDS.The literatures were screened according to the inclusion and exclusion criteria, and the data were extracted for metaanalysis using Stata15.0 software.Results  A total of 4 literatures were included, including 3 observational literatures and 1 multicenter randomized controlled trial.A total of 5 555 patients with high  risk factors for  ARDS  were enrolled, among which 1 537  patients took aspirin. The results showed that  aspirin significantly reduced the incidence of ARDS compared with those who did not take aspirin(OR=0.709,  95%CI=0.5620.896, P=0.004).Conclusion  Prehospital aspirin administration significantly reduces  the incidence of ARDS,but a large number of multicenter randomized controlled trials are needed.

Key words: aspirin, respiratory distress syndrome,  , adult, metaanalysis