Abstract:

Objective To study colorectal adenoma-related risk factors to provide early warning for screening and treatment of early colorectal cancer.Methods Totally 1 126 patients undergoing colonoscopy with a pathological diagnosis of colorectal adenoma in the Second Hospital of Hebei Medical University from January 2014 to June 2020 were enrolled as the case group, current 1 800 patients with negative results as the control group. Multivariate Logistic regression analysis was used to assess the pooled data of gender, age, smoking history, drinking history, bowel habits (whether normal, diarrhea, constipation, diarrhea alternating with constipation), total cholesterol, triglyceride to prove its influence for colorectal adenoma. In order to further excuse the interference of confounding factors, a 1∶1 matching was performed between groups, the independent risk factors for colorectal adenoma were explored by multivariate conditional Logistic regression analysis.Results Multivariate Logistic regression analysis showed that the independent risk factors for colorectal adenoma were gender, age, drinking history, smoking history, bowel habits, total cholesterol and triglyceride (P<0.05); while in multivariate conditional Logistic regression analysis those were bowel habits and triglyceride levels. The risk of colorectal adenoma in patients with chronic diarrhea and chronic constipation was higher than that in patients with normal bowel habits (P<0.05), when patients with higher triglyceride versus with normal triglyceride, increased risk of colorectal adenoma in those higher triglyceride(P<0.05).Conclusion The independent risk factors for colorectal adenoma were bowel habits and triglyceride levels. A higher risk of colorectal adenoma was found in patients with chronic diarrhea and/or chronic constipation and/or elevated triglyceride.

Key words: colorectal neoplasms, bowel habits, triglycerides, risk factors