Abstract:

Objective To understand the characteristics of Helicobacter pylori(H.pylori) infection of children in Qingdao region, and to provide aids for the prevention and treatment of H.pylori infection of children.Methods Four hundred and ninty children received gastroscopy in the Affiliated Hospital of Qingdao University for “repeated abdominal pain, nausea, vomiting, hematochezia”, and other symptoms from June 2016 to June 2021 in Qingdao region, H.pylori infections of children were examined and evaluated based on the results of histopathological and 13C breath test, and the statistical analysis was implemented according to clinical data gathered.Results The overall infection rate of 490 children with H.pylori in Qingdao region was 21.8%. The infection rate of male and female children was 28.1% and 12.6%, and the difference was statistically significant (P<0.05). None of the infection rate of H.pylori differed significantly in different age groups (P>0.05), while the analysis on children aged 7~14 years old showed that the infection rate of H.pylori increased with the age. The H.pylori infection rate of children with highly educated parents was lower than that of children with low educated parents, and with statistically significant difference (P<0.05); the pathological examination of gastric mucosa in 107 children with H.pylori infection showed that there were 4 cases (3.7%) with mild inflammation, 98 cases (91.6%) with moderate inflammation and 5 cases (4.7%) with severe inflammation for inflammation degree as well as 50 mild cases (46.7%), 54 moderate cases (50.5%) and 3 severe cases (2.8%) for inflammatory activity among 107 children.Conclusion The H.pylori infection rate of children in Qingdao region is high, the H.pylori infection rate increases with the age of children aged 7-14 years old. The H.pylori infection rate in children in Qingdao is correlated with gender and parents' education. Pathological examination of gastric mucosa in children infected with positive H.pylori shows that there are more children with moderate inflammation, and the inflammatory activity is mainly mild and moderate.

Key words: helicobacter pylori, children, Qingdao region