Clinical Focus ›› 2022, Vol. 37 ›› Issue (12): 1132-1136.doi: 10.3969/j.issn.1004-583X.2022.12.013
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Received:2022-09-06Online:2022-12-20Published:2023-01-18
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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2022.12.013
| 类别 | CAR-T | CAR-NK | CAR-M | hPSC-CAR-M |
|---|---|---|---|---|
| 细胞来源 | 外周血(自体) | 外周血或脐带血 | 外周血 | 不受限制 |
| 便捷性 | 可冻存,现用现做 | 不可冻存,现用现做 | 不可冻存,现用现做 | 可冻存,及时使用 |
| 异质性 | 异质性 | 异质性 | 异质性 | 同质性 |
| 基因编辑 | 容易,随机 | 困难,随机 | 困难,随机 | 容易,均一100% |
| CRS | 高 | 低 | 中 | 中 |
| GVHD | 高 | 低 | 低 | 低 |
| 细胞库 | 否 | 否 | 否 | 是 |
| 实体瘤效应 | 低 | 低 | 高 | 高 |
| 抗感染 | 无 | 无 | 高 | 高 |
| 类别 | CAR-T | CAR-NK | CAR-M | hPSC-CAR-M |
|---|---|---|---|---|
| 细胞来源 | 外周血(自体) | 外周血或脐带血 | 外周血 | 不受限制 |
| 便捷性 | 可冻存,现用现做 | 不可冻存,现用现做 | 不可冻存,现用现做 | 可冻存,及时使用 |
| 异质性 | 异质性 | 异质性 | 异质性 | 同质性 |
| 基因编辑 | 容易,随机 | 困难,随机 | 困难,随机 | 容易,均一100% |
| CRS | 高 | 低 | 中 | 中 |
| GVHD | 高 | 低 | 低 | 低 |
| 细胞库 | 否 | 否 | 否 | 是 |
| 实体瘤效应 | 低 | 低 | 高 | 高 |
| 抗感染 | 无 | 无 | 高 | 高 |
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