Clinical Focus ›› 2023, Vol. 38 ›› Issue (4): 373-376.doi: 10.3969/j.issn.1004-583X.2023.04.016
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Received:
2022-11-24
Online:
2023-04-20
Published:
2023-06-06
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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2023.04.016
[1] |
Kaya E, Yilmaz Y. Metabolic-associated fatty liver disease (MAFLD): A multi-systemic disease beyond the liver[J]. J Clin Transl Hepatol, 2022, 10(2):329-338.
doi: 10.14218/JCTH.2021.00178 pmid: 35528971 |
[2] | Méndez-Sánchez N, Díaz-Orozco LE. Editorial: International consensus recommendations to replace the terminology of non-Alcoholic fatty liver disease (NAFLD) with metabolic-associated fatty liver disease (MAFLD)[J]. Med Sci Monit, 2021, 27:e933860. |
[3] | Xian YX, Weng JP, Xu F. MAFLD vs. NAFLD: Shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy[J]. Chin Med J (Engl), 2020, 134(1):8-19. |
[4] |
Harrison SA, Bashir MR, Guy CD, et al. Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: A multicentre, randomised, double-blind, placebo-controlled, phase 2 trial[J]. Lancet, 2019, 394(10213):2012-2024.
doi: S0140-6736(19)32517-6 pmid: 31727409 |
[5] |
Harrison SA, Bashir M, Moussa SE, et al. Effects of resmetirom on noninvasive endpoints in a 36-week phase 2 active treatment extension study in patients with NASH[J]. Hepatol Commun, 2021, 5(4):573-588.
doi: 10.1002/hep4.1657 pmid: 33860116 |
[6] |
Younossi ZM, Stepanova M, Taub RA, et al. Hepatic fat reduction due to resmetirom in patients with nonalcoholic steatohepatitis is associated with improvement of quality of life[J]. Clin Gastroenterol Hepatol, 2022, 20(6):1354-1361.
doi: 10.1016/j.cgh.2021.07.039 URL |
[7] |
Caddeo A, Kowalik MA, Serra M, et al. TG68, a novel thyroid hormone receptor-β agonist for the treatment of NAFLD[J]. Int J Mol Sci, 2021, 22(23):13105.
doi: 10.3390/ijms222313105 URL |
[8] |
Caddeo A, Serra M, Sedda F, et al. Potential use of TG68-a novel thyromimetic-for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis[J]. Front Oncol, 2023, 13:1127517.
doi: 10.3389/fonc.2023.1127517 URL |
[9] |
Harrison SA, Neff G, Guy CD, et al. Efficacy and safety of aldafermin, an engineered FGF19 analog, in a randomized, double-blind, placebo-controlled trial of patients with nonalcoholic steatohepatitis[J]. Gastroenterology, 2021, 160(1):219-231.
doi: 10.1053/j.gastro.2020.08.004 pmid: 32781086 |
[10] |
Harrison SA, Abdelmalek MF, Neff G, et al. Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): A randomised, double-blind, placebo-controlled, phase 2b trial[J]. Lancet Gastroenterol Hepatol, 2022, 7(7):603-616.
doi: 10.1016/S2468-1253(22)00017-6 URL |
[11] |
Harrison SA, Ruane PJ, Freilich BL, et al. Efruxifermin in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled, phase 2a trial[J]. Nat Med, 2021, 27(7):1262-1271.
doi: 10.1038/s41591-021-01425-3 pmid: 34239138 |
[12] | Harrison SA, Ruane PJ, Freilich B, et al. A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis[J]. JHEP Rep, 2023, 5(1):100563. |
[13] |
Sanyal A, Charles ED, Neuschwander-Tetri BA, et al. Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: A randomised, double-blind, placebo-controlled, phase 2a trial[J]. Lancet, 2019, 392(10165):2705-2717.
doi: S0140-6736(18)31785-9 pmid: 30554783 |
[14] | Brown EA, Minnich A, Sanyal AJ, et al. Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial[J]. JHEP Rep, 2023, 5(4):100661. |
[15] |
Alkhouri N, Lawitz E, Noureddin M, et al. GS-0976 (Firsocostat): An investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)[J]. Expert Opin Investig Drugs, 2020, 29(2):135-141.
doi: 10.1080/13543784.2020.1668374 URL |
[16] |
Calle RA, Amin NB, Carvajal-Gonzalez S, et al. ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: Two parallel, placebo-controlled, randomized phase 2a trials[J]. Nat Med, 2021, 27(10):1836-1848.
doi: 10.1038/s41591-021-01489-1 pmid: 34635855 |
[17] |
Syed-Abdul MM, Parks EJ, Gaballah AH, et al. Fatty acid synthase inhibitor TVB-2640 reduces hepatic de novo lipogenesis in males with metabolic abnormalities[J]. Hepatology, 2020, 72(1):103-118.
doi: 10.1002/hep.31000 pmid: 31630414 |
[18] |
Loomba R, Mohseni R, Lucas KJ, et al. TVB-2640 (FASN Inhibitor) for the treatment of nonalcoholic steatohepatitis: FASCINATE-1, a randomized, placebo-controlled phase 2a trial[J]. Gastroenterology, 2021, 161(5):1475-1486.
doi: 10.1053/j.gastro.2021.07.025 pmid: 34310978 |
[19] |
Fernández-Ramos D, Lopitz-Otsoa F, Delacruz-Villar L, et al. Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation[J]. World J Gastroenterol, 2020, 26(34):5101-5117.
doi: 10.3748/wjg.v26.i34.5101 URL |
[20] |
Ratziu V, de Guevara L, Safadi R, et al. Aramchol in patients with nonalcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase 2b trial[J]. Nat Med, 2021, 27(10):1825-1835.
doi: 10.1038/s41591-021-01495-3 pmid: 34621052 |
[21] |
Loomba R, Morgan E, Watts L, et al. Novel antisense inhibition of diacylglycerol O-acyltransferase 2 for treatment of non-alcoholic fatty liver disease: A multicentre, double-blind, randomised, placebo-controlled phase 2 trial[J]. Lancet Gastroenterol Hepatol, 2020, 5(9):829-838.
doi: 10.1016/S2468-1253(20)30186-2 URL |
[22] |
Akbari R, Behdarvand T, Afarin R, et al. Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis[J]. BMC Pharmacol Toxicol, 2021, 22(1):53.
doi: 10.1186/s40360-021-00524-8 |
[23] |
Gawrieh S, Noureddin M, Loo N, et al. Saroglitazar, a PPAR-α/γ Agonist, for treatment of NAFLD: A randomized controlled double-blind phase 2 trial[J]. Hepatology, 2021, 74(4):1809-1824.
doi: 10.1002/hep.31843 pmid: 33811367 |
[24] |
Padole P, Arora A, Sharma P, et al. Saroglitazar for nonalcoholic fatty liver disease: A single centre experience in 91 patients[J]. J Clin Exp Hepatol, 2022, 12(2):435-439.
doi: 10.1016/j.jceh.2021.06.015 URL |
[25] |
Younossi ZM, Ratziu V, Loomba R, et al. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: Interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial[J]. Lancet, 2019, 394(10215):2184-2196.
doi: S0140-6736(19)33041-7 pmid: 31813633 |
[26] |
Younossi ZM, Stepanova M, Nader F, et al. Obeticholic acid impact on quality of life in patients with nonalcoholic steatohepatitis: REGENERATE 18-month interim analysis[J]. Clin Gastroenterol Hepatol, 2022, 20(9):2050-2058.
doi: 10.1016/j.cgh.2021.07.020 URL |
[27] |
Patel K, Harrison SA, Elkhashab M, et al. Cilofexor, a nonsteroidal FXR agonist, in patients with noncirrhotic NASH: A phase 2 randomized controlled trial[J]. Hepatology, 2020, 72(1):58-71.
doi: 10.1002/hep.31205 pmid: 32115759 |
[28] |
Alkhouri N, Herring R, Kabler H, et al. Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial[J]. J Hepatol, 2022, 77(3):607-618.
doi: 10.1016/j.jhep.2022.04.003 URL |
[29] |
Harrison SA, Bashir MR, Lee KJ, et al. A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis[J]. J Hepatol, 2021, 75(1):25-33.
doi: 10.1016/j.jhep.2021.01.047 pmid: 33581174 |
[30] |
Friedman SL, Ratziu V, Harrison SA, et al. A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis[J]. Hepatology, 2018, 67(5):1754-1767.
doi: 10.1002/hep.29477 pmid: 28833331 |
[31] |
Ratziu V, Sanyal A, Harrison SA, et al. Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: Final analysis of the phase 2b CENTAUR study[J]. Hepatology, 2020, 72(3):892-905.
doi: 10.1002/hep.31108 URL |
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