Correlation between serum uric acid, homocysteine and cystatin C levels with motor symptoms and cognitive function in Parkinson's disease patients

doi:10.3969/j.issn.1004-583X.2024.02.005

Abstract

Abstract:

Objective To investigate the correlation between serum uric acid (UA), homocysteine (HCY) and cystatin C (Cys C) with motor symptoms and cognitive function in Parkinson's disease (PD) patients. Methods A total of 200 PD patients admitted to Hebei General Hospital from January 2019 to August 2022 were enrolled. They were divided into tremor-dominant (TD) group(n=104) and non-tremor-dominant (NTD) group(n=96) according to first-onset motor symptoms. In addition, the PD patients were grouped also into cognitive normal(PD-CN) group(n=118) and cognitive impairment (PD-CI) group(n=82) according to Montreal Cognitive Assessment. The levels of serum UA, HCY and Cys C of the PD patients were compared. Multivariate logistic regression was used to analyze the risk factors of tremor and cognitive dysfunction in PD patients. Results The patients in TD group had significantly higher serum UA levels, significantly lower Hcy and Cys C levels compared with those of the NTD group (P<0.05). The results from multiple logistic regression analysis showed that UA, HCY, and Cys C were independent risk factors for tremor in PD patients. The patients in the PD-CN group pesented significantly higher serum UA levels, significantly lower HCY and Cys C levels relative to those of the PD-CI group (P<0.05). The results from multivariate logistic regression analysis verifyed that UA, HCY, and Cys C were independent risk factors for cognitive dysfunction in PD patients (P<0.05). Conclusion The serum levels of UA, HCY, and Cys C in PD patients are correlated with motor symptoms and cognitive function.

Key words: Parkinson disease, motor symptoms, cognition, uric acid, homocysteine, cystatin C

CLC Number:

R742.5

Wang Jiuxue, Li Na, Jin Wei, Wang Shuo, Chang Yajun, Wang Tianjun. Correlation between serum uric acid, homocysteine and cystatin C levels with motor symptoms and cognitive function in Parkinson's disease patients[J]. Clinical Focus, 2024, 39(2): 125-129.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.02.005

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I2/125

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References 29

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组别	例数		性别[例(%)]				年龄 (岁)		BMI (kg/m²)		文化程度[例(%)]					高血压病 [例(%)]
组别	例数		男		女		年龄 (岁)		BMI (kg/m²)		小学		中学		高中以上	高血压病 [例(%)]
TD组	104		54(51.92)		50(48.08)		65.51±9.53		25.67±3.35		21(20.09)		72(69.23)		11(10.58)	67(64.42)
NTD组	96		48(50.00)		48(50.00)		66.30±9.39		24.90±3.30		23(23.96)		62(64.58)		11(11.46)	65(67.71)
统计值			χ²=0.125				t=0.352		t=1.750		χ²=1.850					χ²=0.132
P值			0.777				0.555		0.156		0.666					0.877
组别		糖尿病 [例(%)]		冠心病 [例(%)]		吸烟 [例(%)]		饮酒 [例(%)]		认知功能障碍 [例(%)]		UA (μmol/L)		HCY (μmol/L)		Cys C (mg/L)
TD组		32(30.77)		12(11.54)		39(37.50)		21(20.19)		41(39.40)		251.23±84.19		12.4±2.94		0.89±0.08
NTD组		15(15.62)		13(13.54)		40(41.67)		12(12.50)		42(43.80)		249.70±84.71		16.11±6.01		1.01±0.09
统计值		χ²=0.604		χ²=4.405		χ²=0.030		χ²=0.150		χ²=0.230		t=15.360		t=6.927		t=10.650
P值		0.115		0.729		0.929		0.225		0.317		0.026		<0.01		<0.01

组别	例数		性别[例(%)]				年龄 (岁)		BMI (kg/m²)		文化程度[例(%)]					高血压病 [例(%)]
组别	例数		男		女		年龄 (岁)		BMI (kg/m²)		小学		中学		高中以上	高血压病 [例(%)]
TD组	104		54(51.92)		50(48.08)		65.51±9.53		25.67±3.35		21(20.09)		72(69.23)		11(10.58)	67(64.42)
NTD组	96		48(50.00)		48(50.00)		66.30±9.39		24.90±3.30		23(23.96)		62(64.58)		11(11.46)	65(67.71)
统计值			χ²=0.125				t=0.352		t=1.750		χ²=1.850					χ²=0.132
P值			0.777				0.555		0.156		0.666					0.877
组别		糖尿病 [例(%)]		冠心病 [例(%)]		吸烟 [例(%)]		饮酒 [例(%)]		认知功能障碍 [例(%)]		UA (μmol/L)		HCY (μmol/L)		Cys C (mg/L)
TD组		32(30.77)		12(11.54)		39(37.50)		21(20.19)		41(39.40)		251.23±84.19		12.4±2.94		0.89±0.08
NTD组		15(15.62)		13(13.54)		40(41.67)		12(12.50)		42(43.80)		249.70±84.71		16.11±6.01		1.01±0.09
统计值		χ²=0.604		χ²=4.405		χ²=0.030		χ²=0.150		χ²=0.230		t=15.360		t=6.927		t=10.650
P值		0.115		0.729		0.929		0.225		0.317		0.026		<0.01		<0.01

项目	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
项目	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
UA	-0.013	0.004	8.295	0.004	0.987	0.979	0.996
HCY	0.119	0.050	5.778	0.016	1.127	1.022	1.241
CysC	1.302	0.421	7.594	<0.01	4.445	3.221	6.572

项目	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
项目	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
UA	-0.013	0.004	8.295	0.004	0.987	0.979	0.996
HCY	0.119	0.050	5.778	0.016	1.127	1.022	1.241
CysC	1.302	0.421	7.594	<0.01	4.445	3.221	6.572

组别	例数	性别[例(%)]				年龄 (岁)		BMI (kg/m²)		文化程度[例(%)]					高血压病 [例(%)]
组别	例数	男		女		年龄 (岁)		BMI (kg/m²)		小学		中学		高中以上	高血压病 [例(%)]
PD-CN组	118	62(52.54)		56(47.46)		66.38±8.71		25.77±3.35		24(20.34)		82(69.49)		12(10.17)	76(64.41)
PD-CI组	82	40(48.80)		42(51.20)		64.21±8.56		24.80±3.30		20(24.39)		52(63.41)		10(12.20)	56(68.29)
统计值		χ²=0.091				t=0.347		t=0.247		χ²=0.060					χ²=0.141
P值		0.767				0.180		0.166		0.675					0.917
组别	糖尿病 [例(%)]		冠心病 [例(%)]		吸烟 [例(%)]		饮酒 [例(%)]		非震颤症状 [例(%)]		UA (μmol/L)		HCY (μmol/L)		Cys C (mg/L)
PD-CN组	36(30.51)		13(11.02)		39(33.05)		23(29.50)		54(45.8)		300.00±75.74		12.85±5.80		0.95±0.03
PD-CI组	11(13.41)		12(14.63)		40(48.78)		10(12.20)		42(51.2)		265.92±77.19		16.90±5.70		1.05±0.15
统计值	χ²=0.612		χ²=4.130		χ²=0.421		χ²=0.652		χ²=0.240		t=7.860		t=-3.861		t=4.671
P值	0.235		0.789		0.829		0.325		0.269		0.031		<0.01		0.019