Risk factors of seizures in patients with central nervous system cystic echinococcosis

doi:10.3969/j.issn.1004-583X.2024.08.006

Abstract

Abstract:

Objective To investigate the risk factors of seizures in patients with central nervous system (CNS) cystic echinococcosis (CE). Methods A total of 79 patients with CNS CE admitted to the Department of Neurology and Neurosurgery of Qinghai University Affiliated Hospital from January 2016 to January 2024 were enrolled. They were assigned into the seizure group and non-seizure group. Univariate and multivariate logistic regression analyses were used to analyze the risk factors of seizures in patients with CNS CE. Results There were 30 (38.0%) patients with CNS CE in the seizure group. Univariate logistic regression showed that the site, diameter and surrounding brain tissue edema were significantly correlated with the attack of seizure in patients with CNS CE (P<0.05). Multivariate logistic regression showed that cortical localization, and surrounding brain tissue edema were risk factors of seizure in patients with CNS CE (P<0.05). Conclusion The incidence of seizure in patients with CNS CE is 38.0%. Cortical localization, and surrounding brain tissue edema are risk factors of seizure in patients with CNS CE. Targeted approaches can be made to prevent and treat CNS CE.

Key words: echinococcosis, central nervous system diseases, epilepsy, risk factors

CLC Number:

R532.32

Jiao Fei, Yao Zhiping, Wang Langui. Risk factors of seizures in patients with central nervous system cystic echinococcosis[J]. Clinical Focus, 2024, 39(8): 712-715.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.08.006

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I8/712

Figures/Tables 3

Tab.1 Basic data of two groups

组别		例数	年龄(岁)		性别[例(%)]		民族[例(%)]		海拔[例(%)]		包虫类型[例(%)]		头痛[例(%)]
组别		例数	年龄(岁)		男	女	藏族	汉族	中高海拔	高海拔	囊型	泡型	有	无
癫痫发作组		30	39.50±14.38		23(76.7)	7(23.3)	24(80.0)	6(20.0)	5(16.7)	25(83.3)	2(6.7)	28(93.3)	25(83.3)	5(16.7)
非癫痫发作组		49	35.84±13.69		27(55.1)	22(44.9)	41(83.7)	8(16.3)	4(8.2)	45(91.8)	1(2.0)	48(98.0)	43(87.8)	6(12.2)
$t$ /χ²值			-1.132		3.724		0.175		0.624		0.191		0.047
$P$ 值			0.261		0.054		0.678		0.430		0.662		0.829
组别	嗜酸性粒细胞[例(%)]				嗜碱性粒细胞[例(%)]		部位[例(%)]		脑组织受压水肿[例(%)]		直径[例(%)]		病灶数量[例(%)]
组别	正常			异常	正常	异常	皮层	非皮层	有	无	<3 cm	≥3 cm	<3个	≥3个
癫痫发作组	8(26.7)			22(73.3)	23(76.7)	7(23.3)	27(90.0)	3(10.0)	19(63.3)	11(36.7)	27(90.0)	3(10.0)	19(63.3)	11(36.7)
非癫痫发作组	8(16.3)			41(83.7)	32(65.3)	17(34.7)	29(59.2)	20(40.8)	18(36.7)	31(63.3)	33(67.3)	16(32.7)	32(65.3)	17(34.7)
χ²值	1.232				1.135		8.562		5.287		5.227		0.032
$P$ 值	0.267				0.287		0.003		0.021		0.022		0.859

Tab.1 Basic data of two groups

组别		例数	年龄(岁)		性别[例(%)]		民族[例(%)]		海拔[例(%)]		包虫类型[例(%)]		头痛[例(%)]
组别		例数	年龄(岁)		男	女	藏族	汉族	中高海拔	高海拔	囊型	泡型	有	无
癫痫发作组		30	39.50±14.38		23(76.7)	7(23.3)	24(80.0)	6(20.0)	5(16.7)	25(83.3)	2(6.7)	28(93.3)	25(83.3)	5(16.7)
非癫痫发作组		49	35.84±13.69		27(55.1)	22(44.9)	41(83.7)	8(16.3)	4(8.2)	45(91.8)	1(2.0)	48(98.0)	43(87.8)	6(12.2)
$t$ /χ²值			-1.132		3.724		0.175		0.624		0.191		0.047
$P$ 值			0.261		0.054		0.678		0.430		0.662		0.829
组别	嗜酸性粒细胞[例(%)]				嗜碱性粒细胞[例(%)]		部位[例(%)]		脑组织受压水肿[例(%)]		直径[例(%)]		病灶数量[例(%)]
组别	正常			异常	正常	异常	皮层	非皮层	有	无	<3 cm	≥3 cm	<3个	≥3个
癫痫发作组	8(26.7)			22(73.3)	23(76.7)	7(23.3)	27(90.0)	3(10.0)	19(63.3)	11(36.7)	27(90.0)	3(10.0)	19(63.3)	11(36.7)
非癫痫发作组	8(16.3)			41(83.7)	32(65.3)	17(34.7)	29(59.2)	20(40.8)	18(36.7)	31(63.3)	33(67.3)	16(32.7)	32(65.3)	17(34.7)
χ²值	1.232				1.135		8.562		5.287		5.227		0.032
$P$ 值	0.267				0.287		0.003		0.021		0.022		0.859

Tab.2 Multivariate logistic regression analysis of seizures in central nervous system cystic echinococcosis

因素	回归系数	标准误	Wald χ²值	$P$ 值	$O R$ 值	95% $C I$
因素	回归系数	标准误	Wald χ²值	$P$ 值	$O R$ 值	下限	上限
包虫部位	2.775	0.720	14.872	<0.001	16.035	3.914	65.693
周围脑组织受压水肿	1.158	0.584	6.746	0.009	4.562	1.451	14.339
包虫直径	-0.576	0.610	0.892	0.345	0.562	0.170	1.859
常量	-2.812	0.789	12.687	<0.001	0.060

Tab.2 Multivariate logistic regression analysis of seizures in central nervous system cystic echinococcosis

因素	回归系数	标准误	Wald χ²值	$P$ 值	$O R$ 值	95% $C I$
因素	回归系数	标准误	Wald χ²值	$P$ 值	$O R$ 值	下限	上限
包虫部位	2.775	0.720	14.872	<0.001	16.035	3.914	65.693
周围脑组织受压水肿	1.158	0.584	6.746	0.009	4.562	1.451	14.339
包虫直径	-0.576	0.610	0.892	0.345	0.562	0.170	1.859
常量	-2.812	0.789	12.687	<0.001	0.060

Tab.3 Comparison of seizure types

癫痫发作类型	例数	构成比(%)
局灶起始发作
意识清醒/意识障碍	1	3.3
运动症状起病	3	10.0
非运动症状起病	0	0
局灶性进展为双侧强直-阵挛	5	16.7
全面性起源
运动症状起病	2	6.7
强直-阵挛发作	19	63.3
其他运动症状	0	0
非运动症状起病	0	0
起源不明
运动症状起病	0	0
非运动症状起病	0	0
不能分类的发作	0	0

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