大动脉粥样硬化狭窄性脑梗死的危险因素分析

doi:10.3969/j.issn.1004-583X.2016.01.020

临床荟萃 ›› 2016, Vol. 31 ›› Issue (1): 77-80.doi: 10.3969/j.issn.1004-583X.2016.01.020

大动脉粥样硬化狭窄性脑梗死的危险因素分析

张广波¹, 于凯¹, 冀瑞俊², 王拥军², 高素颖¹, 颜应琳¹

1.任丘市燕山南道康济医院神经内科,河北任丘 062550;
2. 首都医科大学附属北京天坛医院神经内科,北京 100050

收稿日期:2015-09-22 出版日期:2016-01-05 发布日期:2016-04-19
通讯作者: 于凯,Email: yk_qj@sina.com

Risk factors for ischemic cerebral infarction in large-artery atherosclerotic stenosis

Zhang Guangbo¹,Yu Kai¹, Ji Ruijun¹,Wang Yongjun², Gao Suying¹,Yan Yinglin¹

1. Department of Neurology,Kangji Hospital,Renqiu 062550,China;
2. Department of Neurology, Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China

Received:2015-09-22 Online:2016-01-05 Published:2016-04-19
Contact: Yu Kai, Email:yk_qj@sina.com

摘要/Abstract

摘要： 目的了解大动脉粥样硬化狭窄性脑梗死与小动脉闭塞性脑梗死危险因素有无不同。方法从河北任丘康济医院神经内科自2014年建立的缺血性卒中急性期干预、二级预防登记研究数据库中根据入组标准抽取了符合标准的736例脑梗死患者。根据有无大动脉狭窄将患者分为2组: 狭窄组303例,平均年龄(64.41±10.9)岁;非狭窄组433例,平均年龄(61.88±11.08)岁。分析大动脉粥样硬化狭窄性脑梗死与小动脉闭塞性脑梗死危险因素有无不同。结果单因素分析年龄、空腹血糖、糖尿病、高密度脂蛋白与大动脉粥样硬化狭窄性脑梗死有关,有统计学意义。以大动脉粥样硬化狭窄性脑梗死为应变量,将单因素分析有意义的自变量进行多因素Logistic回归分析,在校正了空腹血糖等因素后,显示年龄(校正OR=1.024;95% CI=1.010~1.039; P<0.05)、糖尿病(校正OR=1.572;95% CI=1.113~2.219; P<0.05)是大动脉粥样硬化狭窄性脑梗死相关的独立危险因素。而高密度脂蛋白胆固醇(校正OR=0.650;95% CI=0.432~0.977; P<0.05)是大动脉粥样硬化狭窄性脑梗死的保护因素。结论大动脉粥样硬化狭窄性脑梗死与小动脉闭塞性脑梗死危险因素有所不同,糖尿病、年龄是大动脉粥样硬化狭窄性脑梗死的独立危险因素,而高密度脂蛋白胆固醇是大动脉粥样硬化狭窄性脑梗死的保护因素。

关键词: 梗塞, 大脑中动脉, 脑梗死, 危险因素

Abstract: Objective To investigate the risk factors between ischemic cerebral infarction in large-artery atherosclerotic stenosis and small artery occlusive cerebral infarction.Methods The subjects were based on the standard extract of 736 patients with cerebral infarction. According to the presence of artery stenosis, the patients were divided into two groups: stenosis group(303 cases),non-stenosis group(433 cases). The risk factors between ischemic cerebral infarction with large-artery atherosclerotic stenosis and small artery occlusive cerebral infarction were analyzed.Results After adjusting potential confounders, age (adjusted OR=1.024; 95% CI=1.010-1.039; P<0.01), diabetes (adjusted OR=1.572; 95% CI=1.113-2.219; P=0.010) were shown to be significant associates in schemic cerebral infarction with large-artery atherosclerotic stenosis. High density lipoprotein cholesterol(adjusted OR=0.650; 95% CI=0.432-0.977; P<0.05) was the protection factor of ischemic cerebral infarction in large-artery atherosclerotic stenosis.Conclusion Age, diabetes are independent risk factors for ischemic cerebral infarction in large-artery atherosclerotic stenosis. High density lipoprotein cholesterol is the protection factor.

Key words: infarction,middle cerebral artery, brain infarction, risk factors

中图分类号:

R743.3

张广波, 于凯, 冀瑞俊, 王拥军, 高素颖, 颜应琳. 大动脉粥样硬化狭窄性脑梗死的危险因素分析[J]. 临床荟萃, 2016, 31(1): 77-80.

Zhang Guangbo,Yu Kai, Ji Ruijun,Wang Yongjun, Gao Suying,Yan Yinglin. Risk factors for ischemic cerebral infarction in large-artery atherosclerotic stenosis[J]. Clinical Focus, 2016, 31(1): 77-80.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2016.01.020

https://huicui.hebmu.edu.cn/CN/Y2016/V31/I1/77

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大动脉粥样硬化狭窄性脑梗死的危险因素分析

Risk factors for ischemic cerebral infarction in large-artery atherosclerotic stenosis

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