妊娠甲状腺功能亢进患者抗甲状腺药物治疗

doi:10.3969/j.issn.1004-583X.2016.03.006

临床荟萃 ›› 2016, Vol. 31 ›› Issue (3): 254-257.doi: 10.3969/j.issn.1004-583X.2016.03.006

妊娠甲状腺功能亢进患者抗甲状腺药物治疗

李慧,李静

中国医科大学附属第一医院内分泌科,中国医科大学内分泌研究所,辽宁省内分泌疾病重点实验室,辽宁沈阳 110001

收稿日期:2015-10-14 出版日期:2016-03-05 发布日期:2016-04-18
通讯作者: 李静,Email:lijingendocrine@126.com
作者简介:李静，女，1999年毕业于中国医科大学，获医学博士学位。现任中国医科大学附属第一医院内分泌科教授、主任医师、博士和硕士生导师以及中华医学会内分泌学分会青年委员会副主任委员、辽宁省医学会内分泌学分会委员、中国甲状腺学组成员，荣获第四批辽宁省特聘教授。主要研究方向为甲状腺疾病与自身免疫，曾在美国做博士后研究，作为第一负责人承担国家自然科学基金面上项目2项及部省级课题4项，在国内外核心杂志已发表学术论文30余篇。目前是Journal of Cancer Research Updates、《中国实用内科杂志》及《临床内科杂志》等编委、审稿专家以及国家自然科学基金初审专家。
基金资助:
辽宁省高等学校杰出青年学者成长计划 (LJQ2011080);辽宁省教育厅第四批辽宁特聘教授人才项目(16010)

Recent progress in treatment of anti-thyroid drugs on pregnant women with hyperthyroidism

Li Hui,Li Jing

Department of Endocrinology and Metabolism, Institute of Endocrinology,the First Affiliated Hospital of China Medical University,Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China

Received:2015-10-14 Online:2016-03-05 Published:2016-04-18
Contact: Li Jing,Email: lijingendocrine@126.com

摘要/Abstract

摘要： 妊娠合并甲状腺功能亢进(甲亢),尤其是临床甲亢易出现不良妊娠结局,包括子痫、流产、早产、妊娠期糖尿病、胎儿宫内生长受限等,严重威胁孕妇和后代健康。抗甲状腺药物(ATD)是此时治疗甲亢的首选方案,但是近年来研究发现甲巯咪唑和丙基硫氧嘧啶均有致畸作用,此外还可能引起肝损害等严重不良反应,但它们影响的程度不同。因此,如何合理给予ATD治疗妊娠合并甲亢对于保障孕妇和后代健康十分重要,特别应注意严格控制妊娠早期(6～10周)ATD的使用。

关键词: 心房颤动, 血栓栓塞, 左心耳封堵, 甲状腺功能亢进症, 妊娠, 抗甲状腺药

Abstract: Hyperthyroidism in pregnancy, especially overt hyperthyroidism can cause adverse pregnancy outcomes, including eclampsia, abortion, preterm birth,gestational diabetes and fetal intrauterine growth restriction, which is a serious threat to the mother and fetus' health. Anti-thyroid drug (ATD) is the first line of choice for those patients, but recent studies found methimazole and propylthiouracil have teratogenic effects. Moreover, they are possible to cause liver function failure and other serious adverse effects, but the degree is different. Therefore, it is very important to appropriately use ATD to protect the health of mother and fetus, especially to restrict the use in the first trimester of pregnancy (6-10 weeks).

Key words: atrialfibrillation, thromboembolism, percutaneousleftatrialappendagetranscatheterocclusion, hyperthyroidism, pregnancy, antithyroid agents

中图分类号:

R581.1

李慧,李静. 妊娠甲状腺功能亢进患者抗甲状腺药物治疗[J]. 临床荟萃, 2016, 31(3): 254-257.

Li Hui,Li Jing. Recent progress in treatment of anti-thyroid drugs on pregnant women with hyperthyroidism[J]. Clinical Focus, 2016, 31(3): 254-257.

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https://huicui.hebmu.edu.cn/CN/Y2016/V31/I3/254

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妊娠甲状腺功能亢进患者抗甲状腺药物治疗

Recent progress in treatment of anti-thyroid drugs on pregnant women with hyperthyroidism

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