妊娠甲状腺功能亢进症对子代脑发育的影响

doi:10.3969/j.issn.1004-583X.2016.03.007

临床荟萃 ›› 2016, Vol. 31 ›› Issue (3): 258-261.doi: 10.3969/j.issn.1004-583X.2016.03.007

妊娠甲状腺功能亢进症对子代脑发育的影响

刘志红,王瑞英

河北医科大学第二医院内分泌科,河北石家庄 050000

收稿日期:2015-11-09 出版日期:2016-03-05 发布日期:2016-04-18
通讯作者: 王瑞英,Email:wry0616@126.com
作者简介:王瑞英，女，九三学社社员。河北医科大学第二医院内分泌科副主任;主任医师、教授、硕士研究生导师。河北省医学会糖尿病学分会副主任委员；中华医学会微循环学会河北分会委员；河北省糖尿病防治协会常务理事；中国老年保健协会骨代谢与骨质疏松学会副主任委员。从事临床工作30年，熟知内分泌科及代谢性疾病的诊断及治疗，特别是糖尿病并发症及妊娠甲状腺功能改变对母体及子代的影响。先后承担国家十一五科技支撑课题分课题、国际合作课题及多项河北省科技支撑课题、卫生厅及人口及计划生育委员会课题。发表文章40余篇，培养硕士研究生近30人。
基金资助:
河北省科技支撑计划项目(132777132D)

Influence of pregnancy hyperthyroidism on offspring brain development

Liu Zhihong,Wang Ruiying

Department of Endocrinology, the Second Hospital of Heibei Medical University, Shijiazhuang 050000, China

Received:2015-11-09 Online:2016-03-05 Published:2016-04-18
Contact: Wang Ruiying,Email:wry0616@126.com

摘要/Abstract

摘要： 甲状腺激素是大脑发育期的关键激素。妊娠期甲状腺功能异常可引起脑组织和细胞结构的变化。本文分别从妊娠生理、甲状腺激素作用机制及甲状腺功能亢进症(甲亢)方面阐述了甲状腺激素对胎儿大脑发育的不良影响,并从中得出结论:妊娠期甲亢可能影响胎儿大脑发育,需积极治疗。

关键词: 心房颤动, 抗凝治疗, 华法林, 经皮左心耳封堵术, 甲状腺功能亢进症, 甲状腺激素类, 大脑, 妊娠

Abstract: Thyroid hormone (TH) is the key to brain development. Thyroid dysfunction during pregnancy can lead to the change of brain tissue and the cell structure. This review illustrates the adverse effect of thyroid hormone on fetal brain development from hyperthyroidism and mechanism of pregnant physiology and thyroid hormone. The conclusion was that hyperthyroidism during pregnancy may affect fetal brain development and needs active treatment.

Key words: atrialfibrillation, anticoagulanttherapy, warfarin, percutaneousleftatrialappendageocclusion, hyperthyroidism, thyroid hormones, cerebrum, pregnancy

中图分类号:

R581.1

刘志红,王瑞英. 妊娠甲状腺功能亢进症对子代脑发育的影响[J]. 临床荟萃, 2016, 31(3): 258-261.

Liu Zhihong,Wang Ruiying. Influence of pregnancy hyperthyroidism on offspring brain development[J]. Clinical Focus, 2016, 31(3): 258-261.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2016.03.007

https://huicui.hebmu.edu.cn/CN/Y2016/V31/I3/258

参考文献

[1] 单忠艳.妊娠合并甲状腺功能减退症的进展和争论[J].内科理论与实践,2010,5 (2):125-129.
[2] Chan GW, Mandel SJ. Therapy insight: management of Graves’ disease during pregnancy[J]. Nat Clin Pract Endocrinol Metab,2007, 3(6): 470-478.
[3] Haddow JE, McClain MR, Lambert-Messerlian G,et al. Variability in thyroid-stimulating hormone suppression by human chorionic [corrected]gonadotropin during early pregnancy[J]. J Clin Endocrinol Metab, 2008, 93(9): 3341-3347.
[4] Gaberˇcek S, Zaletel K, et al.Thyroid physiology and autoimmunity in pregnancy and after delivery[J]. Clin Immunol, 2011, 7(5): 697-706.
[5] Fister P, Gaberscek S, Zaletel K, et al. Thyroid volume changes during pregnancy and after delivery in an iodine-sufficient Republic of Slovenia[J]. Eur J Obstet Gynecol Reprod Biol,2009, 145(1): 45-48.
[6] Chan SY, Vasilopoulou E, Kilby MD. The role of the placenta in thyroid hormone delivery to the fetus[J].Nat Clin Pract Endocrinol Metab,2009,5(1):45-54.
[7] Wallis K,Dudazy S,Van Hogerlinden M,et al. The thyroid hormone receptor alphal protein is expressed in embryonic postmitotic neurons and persists in most adult neurons[J].Mol Endocrinol,2010,24(10):1904-1916.
[8] Calzà L,Fernández M,Giardino L. Role of the thyroid system in myelination and neural connectivity[J].Compr Physiol,2015, 5(3):1405-1421.
[9] Bhumika S, Darras VM. Role of thyroid hormones in different aspects of nervous system regeneration in vertebrates[J]. Gen Comp Endocrinol, 2014,203:86-94.
[10] Gong J, Liu W, Dong J,et al. Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180[J].BMC Neurosci,2010,11:50.
[11] 叶启宝, 朱德发, 贾雪梅,等. 成年期甲减大鼠海马Muncl8表达及甲状腺素的治疗效应[J]. 安徽医科大学学报, 2009,44(4): 423-426.
[12] Wang F,Zeng X, Zhu Y,et al. Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats[J]. Mol Med Rep,2015,11(2): 775-782.
[13] Zhang HM, Su Q, Luo M. Thyroid hormone regulates the expression of SNAP-25 during rat brain development[J]. Mol Cell Biochem, 2008, 307(1/2): 169-175.
[14] Erdamar H, Demirci H, Yaman H, et al. The effect of hypothyroidism,hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status[J].Clin Chem Lab Med, 2008,46(7):1004-1010.
[15] 王建月, 王茜, 孙春萍,等. 甲状腺激素对成年大鼠额叶内 synaptotagmin 1 表达的影响[J]. 安徽医科大学学报, 2010, 45(6): 752-755.
[16] Giordano T, Pan JB, Casuto D, et al. Thyroid hormone regulation of NGF, NT-3 and BDNF RNA in the adult rat brain[J]. Brain Res Mol Brain Res, 1992,16(3-4): 239-245.
[17] Roberts CG, Ladenson PW. Hypothyroidism[J]. Lancet, 2004, 363(9411): 793- 803.
[18] Vogel A,Elberling TV,Hrding M,et al.Affective symptoms and cognitive functions in the acute phase of Graves'thyrotoxicosis[J].Psychoneuroendocrinology,2007,32(1):36-43.
[19] Ceresini G, Lauretani F, Maqqio M, et al. Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study[J]. J Am Geriatr Soc, 2009, 57(1): 89-93.
[20] Mnnist T, Mendola P, Grewal J,et al.Thyroid diseases and adverse pregnancy outcomes in a contemporary US cohort[J]. J Clin Endcrinol Metab, 2013, 98(7):2725-2733.
[21] Andersen SL, Olsen J, Wu CS,et al. Spontaneous abortion, stillbirth and hyperthyroidism: a danish population-based study[J]. Eur Thyroid J,2014, 3(3): 164-172.
[22] Millar LK,Wing DA,Leung AS,et al,Low birth weight and preeclampsia in pregnancies complicated by hyperthyroidism[J].Obstet Gynecol,1994,84(6):946-949.
[23] Momotani N,Noh JY,Ishikawa N,et al.Effects of propylthiouracil and methimazole on fetal thyroid status in mothers with Graves' hyperthyroidism[J].J Clin Endocrinol Metab,1997,82:3633-3636.
[24] Péter F, Muzsnai A. Congenital disorders of the thyroid: hypo/hyper[J]. Pediatr Clin North Am,2011,58(5): 1099-1115.
[25] Ahmed OM, Abd El-Tawab SM, Ahmed RG. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: I. The development of the thyroid hormones neurotrans- mitters and adenosinergic system interactions[J].Int Dev Neurosci,2010,28(6): 437-454.

妊娠甲状腺功能亢进症对子代脑发育的影响

Influence of pregnancy hyperthyroidism on offspring brain development

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