临床荟萃

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D-二聚体和纤维蛋白原检测在复发性多软骨炎中的临床意义

  

  1. 郑州大学第一附属医院   a.风湿免疫科,河南省高等学校临床医学重点学科开放实验室; b.药学部,河南  郑州 450052
  • 出版日期:2016-09-05 发布日期:2016-08-31
  • 通讯作者: 通信作者:高冠民,Email:guanmingao@medmail.com.cn

Clinical significance of Ddimer and fibrinogen in relapsing polychondritis

  1. a.Department of Rheumatology; b.Department of Pharmacology, the First Affiliated Hospital
    of Zhengzhou University, Zhengzhou 450052,  China
  • Online:2016-09-05 Published:2016-08-31
  • Contact: Corresponding author: Gao Guanmin,Email:guanmingao@medmail.com.cn

摘要: 目的分析D二聚体(DD)和纤维蛋白原(FDP)与复发性多软骨炎(relapsing polychondritis,RPC)的疾病活动及其和呼吸道受累的关系。方法回顾性分析2010年1月至2015年12月在郑州大学第一附属医院确诊的52例RPC的住院患者DD和FDP结果,并比较呼吸道受累和未受累患者DD和FDP结果的差异。结果52例RPC患者中喉、气管、支气管软骨炎等呼吸道受累29例(55.8%),DD和FDP两者或者两者之一升高的患者37例(71.2%),血清DD与血沉(ESR)呈正相关(r=0.635,P=0.000);与C反应蛋白(CRP)呈正相关(r=0.421,P=0.002)。血清FDP与ESR呈正相关(r=0.725,P=0.000);与CRP呈正相关(r=0.689,P=0.000)。RPC患者呼吸道受累与未出现呼吸道损害之间DD差异具有统计学意义(P<0.01),FDP差异无统计学意义(P=0.146)。结论呼吸道受累在RPC中并不少见,而且是影响RPC预后的重要因素。DD和FDP检测对于判断RPC疾病活动具有重要意义,DD和FDP升高和呼吸道受累具有重要关系,可以和ESR、CRP等炎症指标一起作为疾病活动或者严重性的指标。

关键词: 多软骨炎, 复发性; D二聚体;纤维蛋白原

Abstract: ObjectiveTo analyze the clinical significance of Ddimer (DD) and fibrinogen (FDP) in relapsing polychondritis(RPC)and respiratory tract involvement. MethodsA retrospective analysis of  DD and FDP was performed in 52 cases of confirmed RPC patients hospitalized in the First Affiliated Hospital of Zhengzhou University in January 2010  December 2015. And the difference of DD and FDP levels of respiratory tract involvement and noninvolvement patients were compared. Results29 cases (55.8%) in 52 RPC patients were with laryngeal and tracheal, bronchial cartilage inflammation of respiratory tract.37 cases (71.2%) with higher level  DD,FDP or both. Serum DD and blood sedimentation were positively correlated (r=0.635,P=0.000). And the CRP positive correlation (r=0.421,P=0.002).Serum FDP positively related to the blood sedimentation (r=0.725,P=0.000); And CRP (r=0.689,P=0.000).The DD differences between patients with respiratory tract involvement and non  involvement appeared  statistically significant (P<0.001), the difference of FDP had no statistical significance (P=0.146).ConclusionRespiratory tract involvement is not uncommon in RPC, and it is the most important factor influencing the prognosis of RPC.DD and FDP detection are of great significance for determining RPC disease activity, DD and elevated FDP and respiratory tract involvement have important relation, with ESR and CRP,these inflammation markers can be the indexes of disease activity or severity.

Key words: polychondritis, relapsing; Ddimer; fibrinogen