临床荟萃

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嗜酸性食管炎与胃食管反流病关系

  

  1. 北京大学第三临床医学院 消化内科,北京 100191
  • 出版日期:2017-01-05 发布日期:2017-01-12
  • 通讯作者: 通信作者:闫秀娥,Email: pskyq@163.com
  • 作者简介:闫秀娥,女,医学博士,现任北京医学会消化分会青年委员,《中华消化杂志》通讯编委,中华医学会消化分会整合医学学组委员,主持国家自然科学基金一项,参与国家十一五、十二五科技支撑计划及多项省部级课题。科研方向为胃食管反流病,早期胃癌的诊治。

Research progress of relationship between eosinophilic esophagitis and gastroesophageal reflux disease#br#

  1. Department of Gastroenterology, Peking University Third Hospital, Beijing 100191,China
  • Online:2017-01-05 Published:2017-01-12
  • Contact: Corresponding author: Yan Xiue,Email:pskyq@163.com

摘要: 嗜酸性食管炎(EoE)是一种局限于食管的免疫或抗原介导的疾病,以食管黏膜嗜酸细胞浸润为主要特点,与胃食管反流病(GERD)在临床症状和活检病理存在相同之处,且发病机制互相影响,二者有时不易鉴别。本文将从发病机制的相互交叉、临床症状、内镜表现、活检病理及治疗反应等方面来探讨二者之间的关系和异同。

关键词: 食管炎, 消化性:胃食管反流:细胞因子类, 食管内窥镜, 质子泵抑制剂, 诊断, 治疗

Abstract: Eosinophilic esophagitis is currently defined as a chronic, immunemediated or antigenmediated esophageal disease characterized by eosinophilpredominant inflammation. Because of the similarities in clinical symptoms and pathology, it is difficult to identify eosinophilic esophagitis and gastroesophageal reflux disease. The article reviewed the similarities and differences between eosinophilic esophagitis and gastroesophageal reflux disease.

Key words: esophagitis, peptic;gastroesophageal reflux, cytokines, esophagoscopes, proton pump inhibitors, diagnosis;therapy