转化生长因子β1对冠状动脉支架术后再狭窄的预测价值

doi:10.3969/j.issn.1004-583X.2017.03.010

临床荟萃

转化生长因子β1对冠状动脉支架术后再狭窄的预测价值

中国医科大学人民医院辽宁省人民医院辽宁省心血管病医院心内科，辽宁沈阳 110016

出版日期:2017-03-05 发布日期:2017-03-06
通讯作者: 通信作者：侯爱洁，Email: houaijie@medmail.com.cn
基金资助:
沈阳市科技计划项目（F11-262-9-50）

Prediction of transforming growth factor β1 for instent restenosis in patients with coronary artery disease after percutaneous coronary intervention procedure

Department of Cardiology，People's Hospital of China Medical University，Liaoning Province
People’s Hospital， Liaoning Province Cardiology Hospital，Shenyang 110016， China

Online:2017-03-05 Published:2017-03-06
Contact: Corresponding author: Hou Aijie， Email: houaijie@medmail.com.cn

摘要/Abstract

摘要： 目的探讨血清转化生长因子β1（TGFβ1）对冠心病患者经皮冠脉介入术（PCI）后再狭窄的意义。方法对74例PCI术后患者进行冠状动脉造影及光学相干断层成像（OCT）检查，依据冠状动脉造影结果分为再狭窄组和非再狭窄组，比较两组内膜组织覆盖厚度、最狭窄处血管管腔面积、最狭窄处支架面积等，计算支架的最大内膜组织覆盖面积（NA）及支架的内膜组织覆盖面积百分比；术前1天、术后24小时、术后7天、术后6个月行血清TGFβ1检测，并比较PCI前后及两组间差异。结果与非再狭窄组比较，再狭窄组的内膜组织覆盖厚度、内膜组织覆盖面积增加，最小管腔面积减小。与术前比较，再狭窄组、非再狭窄组术后24小时、7天及6个月TGFβ1含量显著升高（P<0.01）。与非再狭窄组比较，术后24小时、7天及6个月再狭窄组的TGFβ1含量显著升高（P<0.01），术后6个月时两组间差异无统计学意义。再狭窄组患者术后的内膜组织覆盖面积百分比与TGFβ1呈显著正相关。结论PCI术后24小时、7天时TGFβ1含量可作为预测冠脉支架术后再狭窄的参考指标。

关键词: 冠状动脉疾病；转化生长因子β1；血管成形术, 经腔, 冠状动脉；冠状动脉再狭窄；体层摄影术, X线计算机

Abstract: ObjectiveTo discuss the significance of transforming growth factor β1 (TGFβ1) for instent restenosis(ISR) in patients with coronary disease after percutaneous coronary intervention (PCI). MethodsPCI procedure was carried out in 74 patients with coronary disease in the hospital. After the procedure， both coronary angiography and optical coherence tomography (OCT) were conducted. According to the results of coronary angiography， the patients were divided into ISR group and nonISR group. The maximal neointimal hyperplasia thickness of stent， minimal lumen area（LA）， stent crosssectional area， the neointimal hyperplasia area， the percentage of the area of the neointimal， diameter stenosis ratio were measured and calculated，respectively. The serum TGFβ1 level was detected 1 day before PCI， 24 hours， 7 days and 6 months after PCI. TGFβ1 levels after PCI in each group were compared. ResultsCompared with nonISR group， both neointimal hyperplasia thickness and area in ISR group were increased significantly. Compared with prePCI， the concentration of TGFβ1 in both ISR group and nonISR group were significantly increased 24 hours，7 days and 6 months after PCI (P＜0.01). The concentration of TGFβ1 at 24 hours 7 days and 6 months after PCI in ISR group were obviously higher than those in nonISR group
(P＜0.01). The percentage of the area of the neointimal was positively correlated to TGFβ1. ConclusionThe concentration of TGFβ1 at 24 hours and 7 days after PCI bears close relationship to the restenosis degree.

Key words: coronary artery disease;transforming growth factor beta 1;angioplasty, transluminal, coronary, coronary restenosis, tomography, Xray computerd

乔兴科，石蕴琦，王永新，李占全，侯爱洁. 转化生长因子β1对冠状动脉支架术后再狭窄的预测价值[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2017.03.010.

Qiao Xingke， Shi Yunqi， Wang Yongxin， Li Zhanquan， Hou Aijie. Prediction of transforming growth factor β1 for instent restenosis in patients with coronary artery disease after percutaneous coronary intervention procedure[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2017.03.010.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2017.03.010

https://huicui.hebmu.edu.cn/CN/Y2017/V32/I3/220

[1]	李朝俊, 孙诚鸿, 金文宇. 非结核分枝杆菌肺病与耐多药肺结核的胸部CT征象对照分析[J]. 临床荟萃, 2021, 36(6): 530-534.
[2]	孙伟. CHA2DS2-VASc评分对急性心肌梗死患者行冠状动脉介入治疗无复流现象预测[J]. 临床荟萃, 2020, 35(9): 792-795.
[3]	苏永才，张小乐，黄志锋，冯新武，苏良献. 超急性期的急性ST段抬高型心肌梗死患者介入治疗临床分析[J]. 临床荟萃, 2020, 35(6): 513-516.
[4]	李思雪，谷国强，刘德敏，王倩，张光明，崔炜. 单核细胞/高密度脂蛋白胆固醇比值不能预测PCI术后对比剂肾病的发生[J]. 临床荟萃, 2020, 35(4): 307-311.
[5]	王海燕1，田丽1，赵颖2，李知娟1，石建平1，傅向华3. 早期肝素化对急性ST段抬高型心肌梗死患者直接经皮冠状动脉介入治疗的疗效[J]. 临床荟萃, 2020, 35(2): 134-138.
[6]	迟红卫，门明，徐倩，冯文秋，任进军，陈艳芳，郭志军. CT靶扫描联合多平面重组对肺部＜1 cm磨玻璃结节诊断的应用价值[J]. 临床荟萃, 2019, 34(9): 823-826.
[7]	王佳旺, 曹绪芬, 徐泽升. 无保护左主干介入治疗[J]. 临床荟萃, 2019, 34(1): 93-96.
[8]	张建华1a，李俊霞1b，刘静2，王荣福1a. 核医学在炎症性肠病中的应用进展[J]. 临床荟萃, 2018, 33(8): 645-649.
[9]	徐倩, 郭志军, 冯文秋, 赵宝宏, 刘海涛, 蔺强. 多排螺旋CT心脏收缩期与舒张期对比测量研究[J]. 临床荟萃, 2018, 33(8): 678-682.
[10]	魏振衡，张军堂. 经皮冠状动脉介入治疗术前单次负荷剂量与常规剂量瑞舒伐他汀对冠心病患者预后的影响[J]. 临床荟萃, 2018, 33(6): 494-497.
[11]	黄平，王晓冬，王伟. 冠状动脉多支病变对急诊经皮冠状动脉介入治疗患者住院期间预后的影响[J]. 临床荟萃, 2018, 33(2): 122-124,128.
[12]	余韬，舒徐. 胃间质瘤预后相关因素的临床研究进展[J]. 临床荟萃, 2018, 33(11): 1008-1012.
[13]	阚方功1a，马周鹏2，林观生2，周平1b. 肾透明细胞癌胰腺转移的CT诊断(附3例报告并文献复习)[J]. 临床荟萃, 2018, 33(10): 904-906,913.
[14]	王春尧，章强，陈慧军. CT技术在评估急性缺血性脑卒中患者侧支循环中的应用[J]. 临床荟萃, 2017, 32(9): 747-751.
[15]	刘晓雨，贾国伟，孙荣国，马博聪，赵明，张红斌，张巍. 替格瑞洛与氯吡格雷对急性冠状动脉综合征患者PCI围术期高敏C反应蛋白的影响[J]. 临床荟萃, 2017, 32(5): 421-424.

转化生长因子β1对冠状动脉支架术后再狭窄的预测价值

Prediction of transforming growth factor β1 for instent restenosis in patients with coronary artery disease after percutaneous coronary intervention procedure

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价