软通道微创颅内血肿清除术联合阿替普酶治疗高血压性小脑出血的疗效

doi:10.3969/j.issn.1004-583X.2017.05.012

临床荟萃

软通道微创颅内血肿清除术联合阿替普酶治疗高血压性小脑出血的疗效

南华大学附属南华医院神经内科，湖南衡阳 421002

出版日期:2017-05-05 发布日期:2017-05-05
通讯作者: 通信作者：李文婷，Email: 1603838803@qq.com
基金资助:
2016年衡阳市科学技术发展计划项目（2016KS13）

Softchannel minimally invasive intracranial hematoma evacuation combined with alteplase on hypertensive cerebellar hemorrhage

Department of Neurology，Affiliated Nanhua Hospital， University of South China，
Hengyang 421002，China

Online:2017-05-05 Published:2017-05-05
Contact: Corresponding author: Li Wenting，Email: 1603838803@qq.com

摘要/Abstract

摘要： 目的对比两种微创血肿清除术联合两种溶栓药治疗高血压性小脑出血的疗效。方法对我院住院的高血压性小脑出血患者40例，采用两种溶栓药（阿替普酶、尿激酶）辅助两种微创手术治疗，随机分为4组，每组10例，收集病例进行临床资料统计分析。对4组治疗前后血肿量、脑水肿量、美国国立卫生研究院卒中量表（National Institute of Health Stroke Scale，NIHSS）评分变化及格拉斯哥预后分级（Glasgow Outcome Scale，GOS）、ADL巴氏指数（Barthel index，BI）评分变化进行对照分析。结果软通道1组在血肿清除率、NIHSS评分及BI评分变化方面较其他3组差异均有统计学意义。在GOS评分方面，软通道1组仅较硬通道1组差异有统计学意义。住院时间方面，软通道1组较硬通道两组差异均有统计学意义。结论软通道微创颅内血肿清除术联合阿替普酶液化引流术能提高小脑出血的救治率。

关键词: 颅内出血, 高血压性；血肿；外科手术, 微创性；通道区；尿激酶型纤溶酶原激活物

Abstract: ObjectiveTo compare the efficacy and safety of soft and hard channel minimally invasive hematoma evacuation combined with two thrombolytic drugs in treatment of hypertensive cerebellar hemorrhage. MethodsForty patients with hypertensive cerebellar hemorrhage hospitalized in the hospital were enrolled. Two thrombolytic drugs (alteplase and urokinase) were used to assist two minimally invasive surgical therapies， the patients were randomized into four groups， each group 10 cases， and the cases were collected for clinical analysis. Hematoma volume and brain edema volume， the changes to the National Institutes of Health Stroke Scale (NIHSS)， the changes to Glasgow Outcome Scale (GOS)， and the changes to ADL Barthel Index (BI) of four groups were analyzed before and after treatment. Results The clearance of hematoma， NIHSS score and BI score in softchannel 1 group were statistically significant compared with those in the other three groups. In GOS score， softchannel 1 group was statistically different compared with only hardchannel 1 group. The length of hospital stay in softchannel 1 group was statistically significant compared with that in two hardchannel groups. ConclusionThe therapy can improve the remedy rate of cerebellar hemorrhage.

Key words: intracranial , hemorrhage, hypertensive；hematoma, surgical procedure, minimally invasive, confined spaces, urokinasetype plasminogen activator

李文婷，陈勇军，蒋福生，刘稀金. 软通道微创颅内血肿清除术联合阿替普酶治疗高血压性小脑出血的疗效[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2017.05.012.

Li Wenting， Chen Yongjun， Jiang Fusheng， Liu Xijin. Softchannel minimally invasive intracranial hematoma evacuation combined with alteplase on hypertensive cerebellar hemorrhage[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2017.05.012.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2017.05.012

https://huicui.hebmu.edu.cn/CN/Y2017/V32/I5/425

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软通道微创颅内血肿清除术联合阿替普酶治疗高血压性小脑出血的疗效

Softchannel minimally invasive intracranial hematoma evacuation combined with alteplase on hypertensive cerebellar hemorrhage

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