关键词: 社区获得性感染, 肺炎 , 药物疗法, 呼吸支持模式

Abstract: Objective  To retrospectively analyze the current status of severe communityacquired pneumonia (SCAP) in Fujian Provincial Hospital.Methods  A total of 88 SCAP patients with communityacquired pneumonia from April 2012 to December 2015 was collected to analyze the current status of drug treatment and respiratory support modes. The treatment of four different etiology groups (including viral, bacterial, combined infection group, and negative group) was compared after the pathogens were detected by highthroughput technology. Results  Among the 88 patients with SCAP, the use of extensive treatment accounted for 4.5%, 18.18%（16/88）  of  which received 1 antibiotic treatment, 42.05% （37/88）  of which received two kinds of antibiotics, 39.78% (35/88) of which received no less than 3 categories. Of all the used antibiotics, βlactams were mostly widely used (87.5%), quinolones were 53.41%, and methicillinresistant Staphylococcus aureus (MRSA) was 37.5%, while the antiviral rate was 26.1%. About 40% of cases used more than 3 kinds of antibiotics in four groups. Patients with combined infection were more likely to use antiMRSA drugs (P<0.05). Noninvasive mechanical ventilation (63.6%) was performed in SCAP patients, 27.3% in simple oxygen therapy, and 9.09% in invasive mechanical ventilation.Conclusion  The antimicrobial treatment of SCAP in our hospital also has different degree of blindness. It is urgent to diagnose early pathogens to guide clinical targeted antimicrobial therapy. The main auxiliary ventilation for severe pneumonia is noninvasive ventilation.

Key words: communityacquired , infections, pneumonia, drug , therapy, respiratory support mode