尿泛素-核糖体融合蛋白52和尿维生素D结合蛋白在糖尿病肾病患者的表达及意义

doi:10.3969/j.issn.1004-583X.2019.06.011

临床荟萃

尿泛素-核糖体融合蛋白52和尿维生素D结合蛋白在糖尿病肾病患者的表达及意义

1.石家庄市第一医院肾内科, 河北石家庄 050011; 2.河北医科大学第三医院肾内科，河北石家庄 050081；
3.中山大学附属第六医院肾内科，广东广州 510655

出版日期:2019-06-20 发布日期:2019-08-02
通讯作者: 刘茂东, Emai:lmdgxh@126.com
基金资助:
河北省科技厅惠民工程---UbA52和VDBP在糖尿病肾病早期诊断中的应用研究(16277754D)；河北省政府资助省级临床医学优秀人才项目---UbA52和VDBP在糖尿病肾病早期诊断中的应用研究

Urine UbA52 and urine VDBP detection and significance in patients with diabetic nephropathy

1.Department of Nephrology, Shijiazhuang First Hospital, Shijiazhuang 050011, China;
2.Department of Nephrology, the Third Hospital of Hebei Medical University, Shijiazhuang 050081, China;
3.Department of Nephrology, the Sixth Affiliated Hospital of Sun Yatsen University, Guangzhou 510655, China

Online:2019-06-20 Published:2019-08-02
Contact: Corresponding author: Liu Maodong，Emai:lmdgxh@126.com

摘要/Abstract

摘要： 目的通过检测尿泛素-核糖体融合蛋白52（UbA52）和尿维生素 D 结合蛋白(VDBP)含量探讨其在糖尿病肾病（DN）诊断中的价值。方法糖尿病肾病患者46例(糖尿病肾病组）、2型糖尿病患者38例(糖尿病组)，以及同期在我院体检的健康者40例作为健康对照组。采用酶联免疫吸附测定（ELISA）法检测尿UbA52、尿VDBP，比较尿UbA52、尿VDBP、24小时尿蛋白定量、尿白蛋白与尿肌酐的比值（ACR）、尿UbA52联合尿VDBP对糖尿病肾病诊断的特异性和敏感性。结果 3组尿UbA52、尿VDBP差异有统计学意义(P＜0.05)，其中DN组尿UbA52、尿VDBP明显高于糖尿病组和健康对照组，糖尿病组与健康对照组差异无统计学意义（P>0.05）。尿UbA52、尿VDBP、24小时尿蛋白定量、ACR、尿UbA52联合尿VDBP诊断DN的ROC曲线下面积分别为0.729、0.776、0.629、0.657、0.779。结论检测尿UbA52、尿VDBP 水平对于评估糖尿病肾病病情有一定参考价值，联合检测尿UbA52与尿VDBP对于糖尿病肾病的诊断有重要的临床意义。

关键词: 糖尿病肾病, 泛素类, 维生素D结合蛋白, 诊断

Abstract: Objective To explore the value of urine ubiquitin 52 amino acid fusion protein(UbA52) and urine vitamin D binding protein(VDBP) in diabetic nephropathy(DN) diagnosis by detecting urine UbA52 and urine VDBP concentrations.Methods A total of 46 patients with DN and 38 patients with type 2 diabetes mellitus were treated as DN group and diabetic group.ELISA was used to detect UbA52 and VDBP in urine. Analysis of differences between three groups, the differences on DN diagnostic specificity and sensitivity in urine UbA52 and urine VDBP, urinary protein quantitative and urinary creatinine ratio (ACR) were compared.Results Urine UbA52 and urine VDBP of three groups were significantly different from each other(P＜0.05). Urine UbA52 and urine VDBP of DN group were significantly higher than those of diabetes group and normal control group.Urine UbA52 and urine VDBP of DN group and normal control group were not significantly different (P＞0.05). The area under the ROC curve of urine UbA52, urine VDBP，24hour urine protein quantification，ACR，urine UbA52 combined urine VDBP in diagnosis of DN were 0.729, 0.776，0.629, 0.657，0.779，respectively.Conclusion The detection of urine UbA52 and urine VDBP levels have certain reference value in evaluating the condition of DN. The combined detection of urine UbA52 and urine VDBP has important clinical significance in diagnosis of DN.

Key words: diabetic nephropathies, ubiquitins, vitamin D binding protein; , diagnosis

王江丽1，刘茂东2，迟雁青2，张益民3，李英2. 尿泛素-核糖体融合蛋白52和尿维生素D结合蛋白在糖尿病肾病患者的表达及意义[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2019.06.011.

Wang Jiangli1, Liu Maodong2, Chi Yanqing2, Zhang Yimin3, Li Ying2. Urine UbA52 and urine VDBP detection and significance in patients with diabetic nephropathy[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2019.06.011.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2019.06.011

https://huicui.hebmu.edu.cn/CN/Y2019/V34/I6/541

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尿泛素-核糖体融合蛋白52和尿维生素D结合蛋白在糖尿病肾病患者的表达及意义

Urine UbA52 and urine VDBP detection and significance in patients with diabetic nephropathy

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