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肺炎支原体感染合并不完全川崎病的危险因素分析

  

  1. 1.福建省妇幼保健院 a.儿科;b.新生儿科; c.重症监护病房、福建医科大学附属医院,福建 福州 350001;
    2.福建省医疗数据挖掘与应用工程技术研究中心,福建 厦门 361024
  • 出版日期:2019-09-20 发布日期:2019-11-19
  • 通讯作者: 王程毅,Email: wangchengyi79@126.com
  • 基金资助:
    福建省医疗数据挖掘与应用工程技术研究中心开放课题——肺炎支原体致川崎病的数据挖掘和知识图谱构建(MDM2018004)

Risk  factors of Mycoplasma pneumonia infection with incomplete Kawasaki disease

  1. 1a.Department of Pediatrics;b.Department of Neonatology;c.Pediatric Intensive Care Unit,Fujian Provincial Maternity and Children’s Hospital,  the Affiliated Hospital of Fujian Medical University,  Fuzhou 350001, China;2. Engineering Research Center for Medical Data Mining and Application of Fujian Province, Xiamen 361024, China
  • Online:2019-09-20 Published:2019-11-19
  • Contact: Corresponding author: Wang Chengyi, Email: wangchengyi79@126.com

摘要: 目的  分析肺炎支原体感染合并不完全川崎病的危险因素。方法  选取2015年1月-2018年12月福建省妇幼保健院儿科收治符合肺炎支原体感染合并不完全川崎病诊断标准的有68例,选取同时期普通病房临床资料完整符合肺炎支原体感染无合并川崎病的病例136例作为对照组,采用单因素分析和多因素二分类Logistic 回归分析的方法分析肺炎支原体感染合并不完全川崎病的危险因素,并对二分类Logistic回归分析有统计学意义的相关指标进行ROC曲线分析。结果  血红蛋白、白蛋白是保护性因素,发热持续时间>7天、混合2种以上病原感染、血小板计数是肺炎支原体感染合并不完全川崎病危险因素;ROC曲线临界值分别为血红蛋白<101 g/L(AUC=0.869,95%CI=0.8140.912)、血小板计数>403×109/L(AUC=0.840,95%CI 0.7830.888)、白蛋白<40.5 g/L(AUC=0.830,95%CI 0.7720.879)、发热时间>7天(AUC=0.761,95%CI 0.6960.818)、混合2种以上病原感染(AUC=0.551,95%CI 0.4800.621)。结论  降低的血红蛋白和白蛋白、升高的血小板计数、发热持续时间>7天、混合2种以上病原感染是肺炎支原体感染合并不完全川崎病的危险因素。

关键词: 肺炎, 支原体, 黏膜皮肤淋巴结综合征, 危险因素

Abstract: Objective  To  investigate the high risk factors of Mycoplasma pneumonia infection with  incomplete Kawasaki disease.Methods  A total of 68patients having  M.pneumonia  infection with incomplete Kawasaki disease were collected from January 2015 to December 2018. At the same time ,a total of 136 patients having  M.pneumonia  infection without Kawasaki disease were selected as a control group. The risk factors of M.pneumonia infection  with incomplete Kawasaki disease were  analyzed by univariate and multivariate binary logistic regression analysis,  and the ROC curve analysis was carried out for relevant indicators with statistical significance in binary Logistic regression analysis.Results  Binary logistic regression analysis showed hemoglobin  and albumin were protective factors, and the fever duration >7 d. The mixed  infection of two or more  pathogensand platelet countwere high risk factors of M. pneumonia infection with incomplete Kawasaki disease. The ROC curve analysis showed that the cutoff values of the 5 predictors were hemoglobin<101 g/L,  area under curve (AUC=0.869,  95%CI 0.8140.912,  platelet count>403×109/L(AUC=0.840,  95%CI 0.7830.888),  albumin<40.5 g/L(AUC=0.830,  95%CI 0.7720.879),  fever duration >7 d(AUC=0.761,  95%CI 0.6960.818),   and the mixed  infection of two or more  pathogens (AUC=0.551,  95%CI 0.4800.621).Conclusion  The reduced hemoglobin and albumin,  increased platelet count,   fever duration >7 d and mixed infection of two or more  pathogens  are risk factors for M. pneumonia infection with  incomplete Kawasaki disease.

Key words: pneumonia, , mycoplasma;mucocutaneous lymph node syndrome, risk factors