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儿童生长激素缺乏症

  

  1. 河北医科大学第二医院 儿科,内分泌遗传代谢专业,河北 石家庄 050000
  • 出版日期:2019-10-20 发布日期:2019-12-09
  • 通讯作者: 张会丰,Email:13333015983@163.com
  • 作者简介:张会丰,河北医科大学二级教授、博士研究生导师。河北医科大学第二医院儿科主任,营养生长发育及内分泌专业主任。河北省儿童糖尿病诊断治疗中心主任,河北省有突出贡献的中青年专家,河北省医学会儿科分会候任主任委员,河北省医学会变态反应学分会主委。

Growth hormone deficiency in children

  1. Department of Paediatrics,  Endocrine and Genetic Metabolism,  the Second Hospital of Hebei Medical University,  Shijiazhuang 050000, China
  • Online:2019-10-20 Published:2019-12-09
  • Contact: Corresponding author: Zhang Huifeng, Email: 13333015983@163.com

摘要: 儿童生长激素缺乏症是导致儿童矮小的原因之一,生长激素激发试验是诊断儿童生长激素缺乏症的重要依据,但也存在假阳性,需要结合生长指标综合评价。生长激素缺乏症分为单纯生长激素缺乏症和多种垂体激素缺乏症,单纯生长激素缺乏症生长激素治疗效果好,需要进行动态的治疗监测,多种垂体激素缺乏症需要激素替代治疗,两者的生长激素缺乏均可能持续至成年期,且单纯生长激素缺乏症可能发展为多种垂体激素缺乏症,需要动态的监测及终身随访。

关键词: 生长激素, 生长激素激发试验, 治疗监测

Abstract: Growth hormone deficiency in children is one of the causes of short stature. Growth hormone stimulation test is an important basis for the diagnosis of growth hormone deficiency in children,  but there are also false positives.And the test, together with target indexes,is comprehensively evaluated. Growth hormone deficiency can be divided into isolated growth hormone deficiency and multiple pituitary hormone deficiency. The growth hormone therapy is effective for isolated growth hormone deficiency,  but dynamic monitoring is needed.  Multiple pituitary hormone deficiency needs hormone replacement therapy. The  growth hormone deficiency of both types may last into adulthood,  and isolated growth hormone deficiency may develop into multiple pituitary hormone deficiency,   and dynamic monitoring and followup for life is needed.

Key words: growth hormone, growth hormone stimulation test, treatment monitoring