关键词: 冠状动脉疾病；睡眠呼吸暂停, , 阻塞性；Gensini评分；肺通气

Abstract: Objective  Obstructive sleep apnea(OSA)  has been considered as a risk factor for coronary heart disease(CHD). This study was designed to investigate the relationship between OSA and coronary artery stenosis. Methods  A total of 420 patients with suspected CHD were selected. All subjects underwent coronary angiography, and Gensini score was calculated to determine the severity of coronary artery stenosis. Then polysomnography was used to determine apnea hypopnea index (AHI). Finally, the correlation between the severity of coronary artery stenosis and OSA was analyzed. Results  Patients with Gensini score ≥80 had higher age, AHI, and prevalence of hypertension, diabetes and OSA than patients with Gensini score <80 (P<0.01). Gensini scores of patients with moderate and severe OSA were significantly higher than those of patients without OSA or with mild OSA (P=0.007, 0.037). Logistic regression analysis found that age, male, AHI, hypertension and diabetes were risk factors for Gensini score ≥80 in the overall population. In the age ≥55 group,  after adjusting for gender and age,  AHI elevation increased the risk of Gensini score ≥80 (OR=1.03,  95%CI:1.001.05, P<0.05). In patients <55 years of age,  the risk of Gensini score ≥80 was 1.77  times higher in patients with diabetes than those without diabetes(OR=2.77,  95%CI: 1.295.94, P<0.05). Conclusion  The severity of coronary stenosis was correlated with AHI. Gensini score was higher in patients with moderate and severe OSA, and it was independently correlated with AHI in patients aged ≥55 years. 

Key words: coronary disease;sleep apnea, , obstructive, Gensini score, pulmonary ventiliation