关键词: 急性冠状动脉综合征, 估算肾小球滤过率, 临床不良事件

Abstract: Objective   To study the effects of different levels of renal function on the inhospital prognosis of patients with acute coronary syndrome(ACS).Methods   According to CKDEPI formula,  the estimated glomerular filtration rate (eGFR) value was obtained. A total of 266 patients with ACS were divided into normal renal function group and mild reduction group,  moderate reduction group,  and severe reduction group.  Retrospective analysis of the incidence of percutaneous coronary intervention (PCI) treatment and other related clinical adverse events among different groups were performed. Results   The proportion of male patients in different renal function levels was significantly higher than that of females,  and the proportion of hypertension was significantly increased in the group of moderate to severe renal insufficiency(P<0.05). Compared with the other three groups,  the normal renal function group had younger age(P<0.01). Multivariate logistics regression analysis showed that elderly patients (≥75 years) and moderate or severe renal function decline increased the risk of heart failure during hospitalization,  and PCI surgery and severe renal function increased the risk of death during hospitalization. Conclusion  In elderly patients (≥75 years),  moderate to severe renal decline may increase the risk of heart failure in patients with ACS. PCI surgery and severe renal decline may increase the risk of death in ACS  patients in hospital.

Key words: acute coronary syndrome, estimated glomerular filtration rate, clinical adverse events