关键词: 皮肌炎, 多发性肌炎, 死亡, 危险因素

Abstract: Objective  To retrospectively summarize the clinical characteristics of patients with dermatomyositis (DM)/polymyositis (PM),  and analyze the independent risk factors of death in DM/PM. Methods  The clinical data of  212 patients who had their first consultation in the Second Hospital of Hebei Medical University from January 2016 to September 2019 and met the idiopathic inflammatory myositis(IIM) classification and diagnosis criteria recommended by the international myopathy cooperation group in 2004 were retrospectively analyzed. The patients were divided into research group (death group) and control group (nondeath group) according to whether they died within half a year or not. The differences in clinical characteristics of patients and laboratory examination between these two groups were analyzed to summarize the independent death risk factors of DM/PM. Results  Two groups showed significant difference in male,  albumin(ALB)<35 g/L,  ferritin increased,  positive antiMDA5 antibody,  pulmonary infection,  interstitial lung disease(P<0.05). Logistic regression analysis showed that  ALB<35  g/L,  ferritin increase,  positive antiMDA5 antibody,  pulmonary infection and interstitial lung disease  closely related to death in DM/PM( P<0.05). Conclusion  Male,  albumin (ALB) <35g/L,   ferritin  increase,  positive antiMDA5 antibody,  pulmonary infection,  and interstitial lung disease were independent risk factors of death in DM/PM,  and suggested poor prognosis.

Key words: dermatomyositis, polymyositis；death； risk factors