关键词: 肺肿瘤, 肺栓塞, 改良Wells评分, 诊断

Abstract: Objective  To evaluate the diagnostic value of modified Wells score in lung cancer complicated with venous thromboembolism(VTE).Methods  A total of 145 patients with lung cancer admitted to the hospital were selected.  The diagnostic value of Wells score and plasma D dimer level in lung cancer with VTE were calculated.Results   The optimal cutoff value of plasma Ddimer for the diagnosis of lung cancer with VTE was 2.51 mg/L. The AUC of Wells score for the diagnosis of lung cancer with VTE was 0.703（95%CI［0.621, 0.776］）, Youden index was 0.407, and the optimal cutoff value was 2 points, with the sensitivity of  66.7% and the specificity of 74%. The AUC of the modified Wells score for the diagnosis of lung cancer with VTE was 0.855（95%CI［0.787，0.908］）, Youden index was 0.543 and the optimal cutoff value was 2 points, with the sensitivity of 93.3%  and the specificity of  61%. The difference of AUC between the modified Wells score and the Wells score in the diagnosis of lung cancer with VTE was statistically significant  （Z=4.712，95%CI［0.088，0.215］，P<0.05）.Conclusion  The modified Wells score is of high diagnostic value for lung cancer with VTE.

Key words: lung neoplasms;pulmonary embolism, improved Wells, diagnosis