临床荟萃

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晚期非小细胞肺癌患者预后相关因素分析

  

  1. 1.四平市肿瘤医院 肿瘤内科,吉林 四平 136001; 2.中国医科大学附属第一医院 肿瘤内科,辽宁 沈阳 110001
  • 出版日期:2016-05-05 发布日期:2016-05-04
  • 通讯作者: 曲卓慧,Email:jlspqzh@sina.com

Factors analysis  of patients prognosis associated  with advanced nonsmall cell lung cancer

  1. 1.Department of Medical Oncology,Siping City Tumour Hospital,Siping 136001,China;
    2.Department of Medical Oncology,the First Hospital of China Medical University,Shenyang 110001,China
  • Online:2016-05-05 Published:2016-05-04
  • Contact: Corresponding author:Qu Zhuohui,Email:jlspqzh@sina.com

摘要: 目的 探讨晚期非小细胞肺癌预后的相关因素。方法 对234例晚期非小细胞肺癌患者的临床资料进
行回顾性分析,对可能影响其预后的相关因素进行单因素和多因素分析。结果 符合纳入标准的非小细胞肺癌患者
234例,选择性别、年龄、吸烟状况、功能状态(PS)评分、病理类型、临床分期6个因素进行单因素分析,其结果显示:PS
评分的相对危险度是1.980(95%CI =1.482~2.646,P <0.05),吸烟状况的相对危险度是1.355(95%CI =1.029~
1.784,P <0.05),提示PS评分及吸烟状况对晚期非小细胞肺癌预后有影响。针对上述两个因素进一步行多因素
COX分析显示:PS评分的相对危险度是2.085(95%CI =1.555~2.796,P <0.05),吸烟状况的相对危险度是1.464 (95%CI =1.109~1.934,P <0.05),提示PS评分、吸烟状况是影响晚期非小细胞肺癌预后的独立因素。结论 PS评分、吸烟状况是影响晚期非小细胞肺癌生存的独立预后因素。

关键词: 癌,非小细胞肺, 预后, 因素分析,统计学

Abstract:

Objective  To study the factors associated with prognosis of advanced nonsmall cell lung cancer(NSCLC).Methods  Retrospective study was performed for clinical data of 234 patients with advanced NSCLC. The potential prognostic factors were evaluated by univariate and multivariate analyses. Results  Of 234 advanced NSCLC cases,six  factors such as gender,age,smoking status, performance status(PS),pathological type and clinical stage were analyzed by univariate analysis, the results showed that the relative risk of PS was 1.980(95%CI  1.4822.646,P<0.05),and the relative risk of smoking status was 1.355(95%CI  1.0291.784,P<0.05), indicating PS and smoking status were related to the prognosis.Further multivariate analysis of the above two factors showed that the relative risk of PS was 2.085(95%CI  1.5552.796,P<0.05),and the relative risk of smoking status was 1.464(95%CI  1.1091.934,P<0.05),PS and smoking status were independent prognostic factors. Conclusion  PS and smoking are the independent factors associated with prognosis of advanced NSCLC.

Key words: carcinoma, nonsmallcell lung, prognosis, factor analysis, statistical