关键词: 糖尿病, 2型, 糖尿病肾病, 甘油三酯类, 腰围

Abstract: ObjectiveTo investigate the association between hypertriglyceridemicwaist phenotype and diabetic kidney disease in patients with type 2 diabetes mellitus(T2DM). MethodsAccording to the cut point of plasma triglycerides concentration ≥1.7  mmol/L， waist circumference ≥85 cm in men or ≥80 cm in women， 753 patients with T2DM were divided into four groups: normal waist circumference and triglycerides， normal waist circumference and hypertriglyceridemia， abdominal obesity and normal triglycerides， and hypertriglyceridemic waist (HTWC) group， DKD incidence and correlation indices were compared， and Logistic regression analysis was adopted for study. ResultsThe body mass index， waist circumference， hip circumference， systolic blood pressure， fasting bloodglucose， uric acid， triglycerides and urinary albumin to creatinine ratio in HTWC group were significantly higher than those in nonHTWC groups (all P<0.01)， as well as DKD incidence (P<0.05). Multiple logistic regression analysis revealed that HTWC was an independent risk factor of DKD (OR=2.014，95%CI=1.1833.625). ConclusionHTWC pyhenotype is significantly related to DKD incidence in T2DM patients.

Key words: diabetes mellitus, type 2;diabetic nephropathies, triglycerides, waist circumference