临床荟萃 ›› 2023, Vol. 38 ›› Issue (6): 554-558.doi: 10.3969/j.issn.1004-583X.2023.06.014
贾丽娜1, 吴美妮1, 尹昌浩2(
)
收稿日期:2022-12-02
出版日期:2023-06-20
发布日期:2023-08-18
通讯作者:
尹昌浩,Email:基金资助:
Received:2022-12-02
Online:2023-06-20
Published:2023-08-18
摘要：
糖尿病是一种慢性代谢性疾病,2型糖尿病(type 2 diabetes,T2DM)至少占所有糖尿病病例的90%。认知功能障碍日益被认为是糖尿病的常见并发症之一。糖尿病认知障碍起病隐匿、病程无法逆转,晚期发展到痴呆后缺少有效的治疗方式,严重影响患者的生存质量。T2DM认知功能障碍可能的机制主要有胰岛素抵抗、炎症和氧化应激、脑微血管功能障碍和淋巴功能障碍、肠道菌群失调、钙稳态失衡等,目前其发病机制尚未完全明确。本文主要对近年来T2DM所致认知功能障碍的发病机制进行综述,以期为认知障碍的早期干预提供思路。
中图分类号:
贾丽娜, 吴美妮, 尹昌浩. 2型糖尿病认知功能障碍发病机制的研究进展[J]. 临床荟萃, 2023, 38(6): 554-558.
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