临床荟萃 ›› 2023, Vol. 38 ›› Issue (8): 753-756.doi: 10.3969/j.issn.1004-583X.2023.08.014
收稿日期:
2023-03-21
出版日期:
2023-08-20
发布日期:
2023-09-28
通讯作者:
王俊祥
E-mail:wjx1191@163.com
Received:
2023-03-21
Online:
2023-08-20
Published:
2023-09-28
摘要:
血清阴性类风湿关节炎(serum negative rheumatoid arthritis,SNRA)是指符合类风湿关节炎的诊断标准,但体内又缺乏对应的自身抗体,这类疾病较血清阳性类风湿关节炎(seropositive rheumatoid arthritis,SPRA)而言更易被忽视,易发生误诊和漏诊。本文对SNRA的发病机制展进行综述,以期提高对SNRP的认识。
中图分类号:
左腾, 王俊祥. 血清阴性类风湿关节炎发病机制的研究进展[J]. 临床荟萃, 2023, 38(8): 753-756.
[1] |
Woude D, Houwing-Duistermaat JJ, Toes R, et al. Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis[J]. Arthritis Rheum, 2009, 60(4):916-923.
doi: 10.1002/art.v60:4 URL |
[2] |
Frisell T, Holmqvist M, Kllberg H, et al. Familial risks and heritability of rheumatoid arthritis: Role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age[J]. Arthritis Rheum, 2013, 65(11): 2773-2782.
doi: 10.1002/art.38097 URL |
[3] |
Thomas F, Karin H, Lars A, et al. Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: A register-based case-control study in Sweden[J]. Ann Rheum dis, 2016, 75(1):183-189.
doi: 10.1136/annrheumdis-2014-206133 pmid: 25498119 |
[4] |
Raychaudhuri S, Sandor C, Stahl EA, et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis[J]. Nat Genet, 2012, 44(3):291-296.
doi: 10.1038/ng.1076 pmid: 22286218 |
[5] |
Woude D, Houwing-Duistermaat JJ, Toes R, et al. Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis[J]. Arthritis Rheum, 2009, 60(4):916-923.
doi: 10.1002/art.v60:4 URL |
[6] |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis[J]. Nat Genet, 2012, 44(12):1336-1340.
doi: 10.1038/ng.2462 pmid: 23143596 |
[7] | Wei WH, Viatte S, Merriman TR, et al. Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis[J]. SciRep, 2017, 7(1): 5261. |
[8] |
Daniela DG, Discacciati A, Orsini N, Wolk A. Cigarette smoking and risk of rheumatoid arthritis: A dose-response meta-analysis[J]. Arthritis Res Ther, 2014, 16(2):R61.
doi: 10.1186/ar4498 URL |
[9] |
Kronzer VL, Westerlind H, Alfredsson L, et al. Respiratory diseases as risk factors for seropositive and seronegative rheumatoid arthritis and in relation to smoking[J]. Arthritis Rheumatol, 2021, 73(1):61-68.
doi: 10.1002/art.v73.1 URL |
[10] |
Wang QQ, Xu R. Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis[J]. BMC Genomics, 2019, 20(1):124.
doi: 10.1186/s12864-019-5510-y pmid: 30744546 |
[11] |
Honda K, Dan RL. The microbiome in infectious disease and inflammation[J]. Annu Rev Immunol, 2011, 30(1):759-795.
doi: 10.1146/immunol.2012.30.issue-1 URL |
[12] |
Rebecca R, Ederveen T, Jos B, et al. Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis[J]. Microbiome, 2017, 5(1):63.
doi: 10.1186/s40168-017-0278-2 pmid: 28645307 |
[13] | 陈晓欢, 洪学志, 刘雷, 等. 肠道菌群失调与类风湿关节炎[J]. 实用医学杂志, 2019, 35(16):5. |
[14] |
Pedersen M, Jacobsen S, Klarlund M, et al. Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides[J]. Arthritis Res Ther, 2006, 8(4):R133.
doi: 10.1186/ar2022 pmid: 16872514 |
[15] |
Lahiri M, Luben RN, Morgan C, et al. Using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis (results from the European Prospective Investigation of Cancer-Norfolk and the Norfolk Arthritis Register--the EPIC-2-NOAR Study)[J]. Ann Rheum Dis, 2014, 73(1):219-226.
doi: 10.1136/annrheumdis-2012-202481 pmid: 23505230 |
[16] |
Klareskog L, Rnnelid J, Saevarsdottir S, et al. The importance of differences; On environment and its interactions with genes, and immunity in the causation of rheumatoid arthritis[J]. J Intern Med, 2020, 287(5):514-533.
doi: 10.1111/joim.13058 pmid: 32176395 |
[17] | De Man YA, Bakker-Jonges LE, Goorbergh DVD, et al. Women with rheumatoid arthritis negative for anti-cyclic citrullinated peptide and rheumatoid factor are more likely to improve during pregnancy, whereas in autoantibody-positive women autoantibody levels are not influenced by pregnancy[J]. Ann Rheu Diseas, 2010, 69(2):420-423. |
[18] |
Bengtsson C, Malspeis S, Orellana C, et al. Association between menopausal factors and the risk of seronegative and seropositive rheumatoid arthritis: Results from the nurses' health studies[J]. Arthritis Care Res (Hoboken), 2017, 69(11):1676-1684.
doi: 10.1002/acr.23194 pmid: 28085997 |
[19] | Pikwer M, Bergstrom U, Nilsson JA, et al. Early menopause is an independent predictor of rheumatoid arthritis[J]. Ann Rheu Diseas, 2012, 71(3):378-381. |
[20] | Sparks JA, Malspeis S, Hahn J, et al. Depression and subsequent risk for incident rheumatoid arthritis among women[J]. Arthritis Care Res(Hoboken), 2021, 73(1):78-89. |
[21] |
Bookwalter DB, Roenfeldt KA, Leardmann CA, et al. Posttraumatic stress disorder and risk of selected autoimmune diseases among US military personnel[J]. BMC Psychiatry, 2020, 20(1):2.
doi: 10.1186/s12888-019-2373-3 |
[22] |
Michot JM, Bigenwald C, Champiat S, et al. Immune-related adverse events with immune checkpoint blockade: A comprehensive review[J]. Eur J Cancer, 2016, 54:139-148.
doi: S0959-8049(15)01112-0 pmid: 26765102 |
[23] |
Vaidya B, Adhikari B, Bhochhibhoya M, et al. Late onset dipeptidyl peptidase-4 inhibitor associated seronegative rheumatoid arthritis[J]. J Nepal Health Res Counc, 2021, 19(3):644-646.
doi: 10.33314/jnhrc.v19i3.3433 pmid: 35140448 |
[24] |
Reed E, Hedström AK, Hansson M, et al. Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity[J]. Arthritis Res Ther, 2020, 22(1):170.
doi: 10.1186/s13075-020-02191-2 |
[25] |
吴滔, 陈楚涛, 杨莉娟, 等. 血清学自身抗体阴性类风湿关节炎患者抗氨基甲酰化蛋白抗体的检测及临床意义[J]. 新医学, 2022, 53(4): 243-248.
doi: 10.3969/j.issn.0253-9802.2022.04.004 |
[26] |
Ponikowska M, Wierkot J, Nowak B, et al. Autoantibody and metalloproteinase activity in early arthritis[J]. Clin Rheumatol, 2019, 38(3):827-834.
doi: 10.1007/s10067-018-4326-5 pmid: 30406565 |
[27] |
Huang F, Liu X, Cheng Y, et al. Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis[J]. Clin Exp Rheumatol, 2021, 39(5):988-994.
doi: 10.55563/clinexprheumatol/vlvlqu pmid: 33427621 |
[28] |
Daigo K, Inforzato A, Barajon I, et al. Pentraxins in the activation and regulation of innate immunity[J]. Immunol Rev, 2016, 274(1):202-217.
doi: 10.1111/imr.12476 pmid: 27782337 |
[29] | Witte T. Methotrexate as combination partner of TNF inhibitors and tocilizumab. What is reasonable from an immunological viewpoint?[J]. Z Rheumatol, 2015, 34(4):629-634. |
[30] |
Szekanecz Z, Mcinnes IB, Schett G, et al. Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases[J]. Nat Rev Rheumatol, 2021, 17(10):585-595.
doi: 10.1038/s41584-021-00652-9 pmid: 34341562 |
[31] |
Floudas A, Canavan M, Mcgarry T, et al. ACPA status correlates with differential immune profile in patients with rheumatoid arthritis[J]. Cells, 2021, 10(3):647.
doi: 10.3390/cells10030647 URL |
[1] | 李阳, 默峰, 辛志飞, 王倩, 邓新娜. 特殊临床表现多系统免疫相关不良事件1例[J]. 临床荟萃, 2023, 38(7): 633-637. |
[2] | 贾丽娜, 吴美妮, 尹昌浩. 2型糖尿病认知功能障碍发病机制的研究进展[J]. 临床荟萃, 2023, 38(6): 554-558. |
[3] | 肖梦, 程婷婷, 马倩格, 冯晓颖, 李利华, 李涛. 承德地区EB病毒感染和传染性单核细胞增多症患儿临床特点[J]. 临床荟萃, 2023, 38(6): 526-531. |
[4] | 邹琳, 崔轶霞, 张娜娜, 陈思荣. 类风湿关节炎合并骨质疏松症发病机制和相关治疗药物对骨质疏松症影响的研究进展[J]. 临床荟萃, 2023, 38(3): 279-284. |
[5] | 彭艳, 白碧玥, 朱晓峰, 尹昌浩. 酒精使用障碍患者认知功能损害发病机制的研究进展[J]. 临床荟萃, 2023, 38(12): 1131-1134. |
[6] | 何培华, 周幸福, 洪炜鸿, 王利纯, 刘素君, 金玉燕, 曾佳豪, 刘立昌. IgG4相关性肾病4例临床分析[J]. 临床荟萃, 2023, 38(11): 1016-1021. |
[7] | 杨晓蓉, 周淑红, 潘亮, 郭莉江. 结缔组织病相关肺动脉高压的发病机制及其筛查的研究进展[J]. 临床荟萃, 2023, 38(10): 944-948. |
[8] | 曾晓晴, 庄伟端, 陈丽芬. 卒中后癫痫发作发病机制的研究进展[J]. 临床荟萃, 2022, 37(2): 174-177. |
[9] | 杨林红, 钱宝堂, 郝应禄, 李燕萍, 赵静思. 与心脏疾病相关的肺栓塞临床研究现状[J]. 临床荟萃, 2021, 36(3): 285-288. |
[10] | 张慧卿,路延朋,宋学琴. CAPN3基因突变导致的Calpainopathy的发病机制、临床表现和实验室检测研究进展[J]. 临床荟萃, 2020, 35(6): 564-567. |
[11] | 杜忠彩1,刘玉2,周欣蓓2,赵婉君2, 苏媛2. 秋水仙碱中毒患者30例临床荟萃分析[J]. 临床荟萃, 2020, 35(4): 362-368. |
[12] | 李官红a, 李文a, 曾剑b, 张宇a, 邱清萍a, 郑玉琼a. 12例新型冠状病毒肺炎患者临床特征分析[J]. 临床荟萃, 2020, 35(11): 1005-1009. |
[13] | 李晶雪,李哲,王天俊. 帕金森病伴发抑郁发病机制及治疗的研究进展[J]. 临床荟萃, 2019, 34(8): 759-763. |
[14] | 李晶雪,王天俊. 卒中后抑郁发病机制及治疗研究进展[J]. 临床荟萃, 2019, 34(6): 572-576. |
[15] | 冯三丽1, 2,张静楠2,乔淑凯2,王文飞1,李扬2,邢丽娜2,郭晓楠2. 原发性骨髓纤维化伴阵发性睡眠性血红蛋白尿1例并文献复习[J]. 临床荟萃, 2019, 34(12): 1119-1122. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||