关键词: 造血干细胞移植, 巨细胞病毒感染, 危险因素, 移植物抗宿主病

Abstract: ObjectiveTo analyze the clinical characteristics  of cytomegalovirus(CMV) infection after  human leukocyte antigen（HLA） haploidentical peripheral blood hematopoietic stem cell transplantation（HDIPBSCT） and the effect of the preemptive treatment. MethodsThe study enrolled 69 patients who underwent HDIPBSCT in the Department of Hematology of our hospital from Mar 2010 to Mar 2015. The CMV infection rate， the median time when CMVDNA was positive at the first time， the response rate of the preemptive treatment and the median time of CMVDNA turning negative were analyzed. Fiveyear survival rate was compared between the patients with or without CMV infection. ResultsThe results indicated that CMV viremia was 73.9％(51/69).The median time of CMV when CMVDNA was positive at the first time was 36 d（14120 d）after HIDPBSCT．After the preemptive treatment， 80.4%（41/51） of the patients with CMV viremia turned negative. The median time of CMVDNA turning negative were 21 d（782 d）， only two patients died of CMV pneumonia. Fiveyear survival rate of the patients with or wihout CMV viremia was  respectively  52.9% and 50% (P>0.05). ConclusionThe incidence of CMV infection is high after HIDPBSCT. The preemptive treatment can effectively prevent the progression of CMV viremia to CMV disease.

Key words: hematopoietic stem cell transplantation； cytomegalovirus infections, risk factors, graft vs host disease