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炎性标记物与脓毒症患者病情严重程度量化关系

  

  1. 1.兰州军区兰州总医院 呼吸内科,甘肃  兰州 730050;2.酒泉市人民医院  呼吸科,甘肃  酒泉  735000
  • 出版日期:2016-11-05 发布日期:2016-11-04
  • 通讯作者: 通信作者:贾金虎,Email:jiajinhu1987@163.com

Quantitative relationship between inflammatory markers and sepsis  severity

  1. 1.Department of Respirotary Medicine,Lanzhou General Hospital of Military Command,
    Lanzhou  730050,China;  2.Department of Respirotary Medicine,Jiuquan People's Hospital,
    Jiuquan 735000,China
  • Online:2016-11-05 Published:2016-11-04
  • Contact: Corresponding author: Jia Jinhu,Email:jiajinhu1987@163.com

摘要: 目的探讨脓毒症患者血清中炎性标记物超敏C反应蛋白水平(hsCRP)水平、降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)等炎性标记物与脓毒症病情严重程度的定量关系。方法收集符合脓毒症诊断标准的合格脓毒症患者83例,根据病情严重程度分为脓毒症组和严重脓毒症组,并记录患者一般状况后于第2日清晨抽取静脉血8 ml送检测定CRP、PCT、hsCRP、WBC等炎性标记物水平,计算死亡风险系数。结果经多分类多元回归模型分析后可知hsCRP、PCT水平与脓毒症患者病情严重程度有关联。结论hsCRP、血沉、PCT水平对脓毒症患者病情严重程度具有一定指导意义。

关键词: 脓毒症, C反应蛋白质, 降钙素受体样蛋白

Abstract: ObjectiveTo investigate the quantitative relationship between the concentration of ultra sensitive C response protein (hsCRP) in all kinds of sepsis patients’ blood and the severity of sepsis. MethodsEightythree sepsis patients were selected, then grouped according to the severity of the disease and scored according to basic information of each patient. The blood sample 8 ml was extracted and CRP,hsCRP, WBC, N(%) were measured  and coefficient of death risk was calculated. ResultsLogistic regression model showed that hsCRP,PCT concentration, erythrocyte sedimentation rate (ESR) were associated with sepsis severity of patients. ConclusionThe concentration of inflammatory cytokines,hsCRP, ESR, PCT have certain guiding significance on sepsis severity evaluation.

Key words: sepsis, Creactive protein, calcitonin receptorlike protein