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阻塞型睡眠呼吸暂停低通气综合征与ApoB/ApoAⅠ的相关性分析

  

  1. 1.包头医学院,内蒙古 包头 014040;2.锦州医科大学第三医院,辽宁 锦州  121000;
    3.包头医学院第二附属医院 心内科, 内蒙古 包头 014030
  • 出版日期:2017-01-05 发布日期:2017-01-12
  • 通讯作者: 通信作者:孙刚,Email:sgsungang@vip.sina.com

Correlation between obstructive sleep apnea hypopnea syndrome and ApoB/ApoAⅠ

  1. 1.Baotou Medical College,Baotou 014040,China;2.The Third Affiliated Hospital of
    Jinzhou Medical University,Jinzhou 121000,China;3.Department of Cardiology,
    the Second Affiliated Hospital of Baotou Medical College,Baotou 014030,China
  • Online:2017-01-05 Published:2017-01-12
  • Contact: Corresponding author: Sun Gang, Email:sgsungang@vip.sina.com

摘要: 目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与ApoB/ApoAⅠ的相关性。方法收集单纯鼾症患者29例,OSAHS患者50例的基本信息及甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、LDLC/HDLC、ApoAⅠ、ApoB、ApoB/ApoAⅠ、血糖(Glu)、血尿酸(UA)、睡眠监测结果。结果OSAHS组血ApoB/ApoAⅠ、BMI较对照组明显增加(P<0.05),两组TG、TC、HDLC、LDLC、LDLC/HDLC、ApoAⅠ、ApoB、Glu、UA、年龄、性别、口服降脂药情况差异均无统计学意义(P>0.05)。并且,ApoB、ApoB/ApoAⅠ、BMI与呼吸暂停低通气指数(AHI)呈正相关(r=0.243、0.298、0.281,P<0.05)。结论肥胖是OSAHS的重要危险因素,并且BMI与AHI呈正相关。OSAHS患者与单纯鼾症患者相比血ApoB/ApoAⅠ明显升高,并且血ApoB、ApoB/ApoAⅠ与OSAHS严重程度正相关。

关键词: 睡眠呼吸暂停综合征, 载脂蛋白A Ⅰ, 载脂蛋白B类

Abstract: ObjectiveTo investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and ApoB/ApoAⅠ. MethodsTwentynine patients with only snoring and 50 patients with OSAHS were enrolled. The baseline data, laboratorial index(TG, TC, HDLC, LDLC, LDLC/HDLC,ApoAⅠ, ApoB,ApoB/ApoAⅠ,Glu,UA) and sleep monitoring results (AHI) of all patients were collected. ResultsCompared with the control group,ApoB/ApoAⅠ  and  BMI were significantly increased in OSAHS group (P<0.05). TG, TC, LDLC, HDLC, LDLC/HDLC, ApoAⅠ, ApoB, Glu, UA,age, gender and oral lipidlowering drug showed no significant difference between two groups(P>0.05). Moreover,  ApoB, ApoB/ApoAⅠ, BMI showed  linear correlation with AHI  respectively (r=0.243,r=0.298,r=0.281,respectively,P<0.05). ConclusionObesity was a major risk factor of OSAHS, BMI and AHI were positively correlated. Compared with the control group the apoB/ApoAⅠ increased significantly in OSAHS group,  apoB and apoB/ApoAⅠ and the severity of OSAHS were positively correlated.

Key words: sleep apnea syndromes, apolipoproteins A Ⅰ, apolipoproteins B