临床荟萃

• 论著 • 上一篇    下一篇

高血压患者补体C3水平及其与载脂蛋白B的关系

  

  1. 1.新疆医科大学第一附属医院  干部病房内二科,新疆 乌鲁木齐 830054;  2.老河口市第一医院  老年病科,湖北 老河口 441800
  • 出版日期:2017-09-05 发布日期:2017-09-08
  • 通讯作者: 通信作者:高颖, Email:sunflorwergaoying@163.com
  • 基金资助:
    新疆维吾尔自治区科技支疆计划项目(2016E02074)

Complement C3 level and relationship with apolipoprotein B in essential hypertension patients

  1. 1.Department of Internal Medicine, the First Affiliated Hospital of Xinjiang Medical University,
    Urumqi 830054, China;  2.Department of Geriatrics, the First Hospital of Laohekou, Laohekou 441800, China
  • Online:2017-09-05 Published:2017-09-08
  • Contact: Corresponding author: Gao Ying, Email:sunflorwergaoying@163.com

摘要: 目的  探讨原发性高血压患者补体C3的表达水平及其与载脂蛋白B(ApoB)的关系。方法  58例原发性高血压患者为观察组,48例非原发性高血压患者为对照组,比较补体C3、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、载脂蛋白A1(ApoA1)、ApoB等指标,分析补体C3与ApoB的关系。结果  观察组补体C3、TG、TC、LDLC、 ApoB均高于对照组(P<0.05)。观察组补体C3与BMI、ApoB呈正相关(P<0.05),ApoB与补体C3、TG、TC、LDLC呈正相关(P<0.05),多元逐步回归分析显示ApoB与补体C3互有影响。结论  原发性高血压患者补体C3与ApoB具有一定的相关性。

关键词: 高血压, 补体C3, 载脂蛋白B类, 心血管疾病

Abstract: Objective  To investigate complement C3 level  and relationship with apolipoprotein B in patients with essential hypertension. Methods  Observational group was composed of 58 patients with essential hypertension, and another 48 participants with nonessential hypertension were selected as control group. Relationship between complement C3 and apolipoprotein B was analyzed according to comparison of complement C3, triglyceride(TG), total cholesterol(TC), high density lipoprotein cholesterol(HDLC), low density lipoprotein cholesterol(LDLC), apolipoprotein A1, apolipoprotein B(ApoB), body mass index, age, gender and other indicators. Results  The complement C3, TG, TC, LDLC and ApoB were significantly higher in observational group than those in control group (P<0.05). There was positive correlation between complement C3 with ApoB in observation group (P<0.05). There was positive correlation between ApoB and C3, TG, TC, LDLC in observation group (P<0.05). There was correlation between complement C3 and ApoB in multiple linear regression. Linear regression analysis showed that complement C3 was positively correlated with ApoB (P<0.05), with ApoB as the dependent variable and complement C3 as the independent variable. Conclusion  In patients with essential hypertension, complement C3 and apolipoprotein B are correlated, and the interaction between two groups also affects mutually.

Key words: hypertension, complement C3, apolipoprotein B, cardiovascular diseases