关键词: 急性冠状动脉综合征, 血小板, Gensini评分

Abstract: Objective    To investigate the association between platelet parameters and the clinical classification and the severity of coronary artery disease in patients with acute coronary syndrome(ACS). Methods    A total of 262 patients with ACS were divided into STEMI group (n=167)， NSTEMI group (n=30) and UAP group (n=65). The severity of coronary stenosis was quantitated by Gensini score system. The clinical data of three groups were compared， the correlation between Gensini score and clinical indexes were analyzed. Results    There were significantly higher levels of age， hsCRP， mean platelet volume and platelet distribution width in STEMI group and NSTEMI group than in UAP group（P<0.05）， MPV and PDW in STEMI group were significantly higher than those of NSTEMI group（P<0.05）. Correlation and regression analysis showed there were significant positive correlations between MPV， PDW and hsCRP levels and coronary lesions and Gensini score in all patients with  ACS. Conclusion    MPV and PDW levels were significantly different in patients with different ACS types， and the levels of MPV and PDW were positively correlated with the severity of coronary artery lesions in patients with ACS， which could be used as predictors of the severity of coronary artery lesions in patients with ACS.

Key words: acute coronary syndromes, blood , platelets, gensini score