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γ-谷氨酰转移酶在冠心病不同性别及病变支数的变化

  

  1. 玉溪市人民医院 检验科,云南 玉溪 653100
  • 出版日期:2017-10-05 发布日期:2017-10-10
  • 通讯作者: 通信作者:冯磊, Email:fngj2004@163.com
  • 基金资助:
    云南省教育厅一般项目(2011C083)

Change of  γ-glutamyltransferase in different sex and lesions number  with coronary  heart disease

  1. Department of Laboratory,   People′s Hospital of Yuxi,   Yuxi  653100,  China
  • Online:2017-10-05 Published:2017-10-10
  • Contact: Corresponding author: Feng Lei, Email:fngj2004@163.com

摘要: 目的  从不同性别入手,探讨γ谷氨酰转移酶(γglutamyltransferase,GGT)在冠心病(coronary heart disease, CHD)诊断或评估中的价值,及与其他传统指标的相关性,全面认识GGT在CHD中的运用价值。方法 分别比较相同性别、不同性别病例组与对照组间GGT的差异,通过相关性分析GGT与CHD及其他传统指标的关系,通过ROC曲线了解GGT在CHD中的诊断效能。结果 对照组不同性别间、女性病例组和对照组间GGT差异有统计学意义。女性GGT与是否患CHD具有很强的正相关,与年龄、高密度脂蛋白胆固醇、载脂蛋白(APOA)、同型半胱氨酸存在一定相关性;女性GGT水平与是否患病的ROC曲线下面积达到0.793。结论 GGT与CHD相关性存在性别差异,男性GGT与CHD无关,女性GGT升高与CHD存在正相关,女性GGT水平在判断是否患CHD方面具有较高诊断效能,而与病变支数关系不明显。

关键词: 冠状动脉疾病;性别;&gamma, -谷氨酰转移酶

Abstract: Objective  To overall explore the diagnostic and estimated value of γglutamyltransferase(GGT) in different sex of coronary heart disease(CHD), to study the correlation with other items. Methods  The difference in GGT  in same and different sex  between test group and control group, the relationship between GGT and traditional factors were studied through the correlation analysis, the diagnostic value of GGT in CHD was evaluated by ROC curve. Results  GGT showed significant difference between different sex in control group and in female between control and test group. There was no correlation with CHD but certain correlation with TG in male. On the other hand, there was positive correlation with CHD, correlation with age, HDLC, APOA, HCY in female. The area of ROC curve in diagnosis CHD by the value of GGT in female was 0.793. Conclusion  The correlation of GGT with CHD has significant difference in different sex, there is no correlation with CHD in male, there is significant  positive correlation with CHD in female.  GGT  has great value in diagnosis CHD  in female, but there is no correlation with lesions number.

Key words: coronary disease; , sex; , γ-glutamyltransferase