临床荟萃

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维持性血液透析患者血管钙化特点及影响因素分析

  

  1. 1.桂林市人民医院  肾内科, 广西 桂林   541002;2.桂林市第二人民医院 肾内科,广西 桂林   541002
  • 出版日期:2017-10-05 发布日期:2017-10-10
  • 通讯作者: 通信作者: 周凡力,Email: 564021954@qq.com
  • 基金资助:
    桂林市科学研究与技术开发计划(2016012704-1)

Characteristics and influencing factors of  vascular calcification in maintenance hemodialysis patients

  1. 1.Department of Nephrology,  Guilin People's Hospital,  Kuilin 541002,  China; 
    2.Department of  Nephrology,  Guilin Second People's Hospital,  Kuilin 541002,  China
  • Online:2017-10-05 Published:2017-10-10
  • Contact: Corresponding author: Zhou Fanli, Email: 564021954@qq.com

摘要: 目的 对维持性血液透析(MHD)患者血管钙化特点及影响因素进行探讨分析。方法 对126例MHD患者的临床资料进行回顾性分析,其中血管钙化评分≥3分(中重度)52例,血管钙化评分<3分(轻度)74例,分析影响血管钙化发生的相关因素。结果 两组性别、年龄、糖尿病、高血压史、成纤维细胞生长因子(FGF23)、每日服用钙剂的剂量及校正血钙及钙磷乘积水平比较差异有统计学意义(P<0.05)。年龄、透析龄、糖尿病及超敏C反应蛋白(hsCRP)是MHD患者发生血管钙化的独立危险因素。结论 MHD发生血管钙化较为普遍,性别、年龄、糖尿病史、高血压史、校正血钙、钙磷乘积均是影响血管钙化发生的因素。

关键词: 肾透析, 血管钙化, 危险因素

Abstract: Objective To investigate the characteristics and influencing factors of vascular calcification in maintenance hemodialysis patients. Methods  The clinical data of 126 patients with maintenance hemodialysis were retrospectively analyzed. The indexes of maintaining blood dialysis patients and the effect of  risk factors for vascular calcification were analyzed. Results  The two groups showed significant differences in gender, age, diabetes mellitus, hypertensive history, fibroblast growth factor (FGF23), daily dose of calcium and corrected serum calcium and multiplication of calcium and phosphorus levels (P<0.05). Age, dialysis age, diabetes mellitus and high sensitivity Creactive protein (hsCRP) were independent risk factors for   vascular calcification  in patients with maintenance hemodialysis. Conclusion  The patients with vascular calcification is common in hemodialysis, and gender, age, diabetes  history, hypertension, correction of calcium, calcium and phosphorus product are all  risk factors of  vascular calcification.

Key words: renal dialysis, vascular calcification, risk factors