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下肢深静脉血栓形成的危险因素分析

  

  1. 新疆维吾尔自治区人民医院 a.肝胆外科; b.血管外科,新疆  乌鲁木齐 830001
  • 出版日期:2018-01-05 发布日期:2018-01-22
  • 通讯作者: 通信作者:戈小虎, Email:gexiaohu_xj@163.com
  • 基金资助:
    通信作者:戈小虎, Email:gexiaohu_xj@163.com

Risk factors of deep venous thrombosis

  1. a.Department of Hepatobiliary Surgery; b. Department of Vascular Surgery,
    People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
  • Online:2018-01-05 Published:2018-01-22
  • Contact: Corresponding author: Ge Xiaohu, Email:gexiaohu_xj@163.com

摘要: 目的 研究下肢深静脉血栓形成(deep venous thrombosis,  DVT)的危险因素。方法 对新疆维吾尔自治区人民医院血管外科收治的下肢深静脉血栓患者及同时期体检的健康人群行病例对照实验,通过问卷调查、实验室检查等,研究该疾病的危险因素,并使用logistics回归模型对危险因素进行综合分析。结果 两组间水果摄入(P<0.01)、妊娠/产褥期(P<0.05)、血浆抗凝血酶Ⅲ(ATⅢ)浓度(P<0.05)、蛋白C(PC)浓度(P<0.05)、同型半胱氨酸(Hcy)浓度(P<0.05)及叶酸浓度(P<0.05)差异统计学意义。使用多因素logistic回归对筛选后的因素进行分析后发现,体重指数(BMI)(OR=1.082,95%CI=1.014~1.154)、妊娠/产褥期(OR=5.038,95%CI=1.752~14.490)、血浆ATⅢ浓度降低(OR=0.937,95%CI=0.920~0.953)及Hcy浓度增高(OR=1.084,95%CI=1.047~1.122)可能是DVT的独立危险因素。结论 血浆ATⅢ浓度及Hcy浓度与DVT密切相关,前者的浓度降低及后者的浓度增高可能增加DVT患病的风险;妊娠/产褥期及血清叶酸浓度降低是DVT的危险因素。

关键词: 血栓性静脉炎, 危险因素, Logistic回归分析

Abstract: Objective  To explore the risk factors of the deep venous thrombosis(DVT). Methods  A casecontrol study was carried on DVT patients and healthy population in People's Hospital of Xinjiang Uygur Automous Region, the risk factors for the disease were explored through questionnaire and laboratory examination, synthetic analysis was made in the risk factors by logistic regression model. Results  Fruit intake(P<0.01), pregnancy/puerperium(P<0.05), ATⅢ(P<0.05), protein C(P<0.05), Hcy(P<0.05) and folic acid(P<0.05) had statistic difference between two groups. After screening the discovery with multiariable logistic regression analysis, BMI(χ2=5.59,P=0.018,OR=1.082, 95%CI=1.0141.154), gestation(χ2=9.002, P=0.003, OR=5.038, 95%CI=1.75214.490), plasma levels of ATⅢ(χ2=54.135,P<0.01,OR=0.937,95%CI=0.9200.953) and Hcy(χ2=20.384,P<0.001,OR=1.084,95%CI=1.0471.122) were independent risk factors for DVT. Conclusion  The plasma concentration of ATⅢ and Hcy are closely related with DVT. Fruit intake, pregnancy/puerperium and serum folate concentration are the influence factors of DVT.

Key words: thrombophlebitis, risk factors, logistic regression analysis