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云南傣族人群糖化血红蛋白及糖化血清蛋白分布情况分析

  

  1. 昆明医科大学第六附属医院 检验科,云南 玉溪 653100
  • 出版日期:2018-07-05 发布日期:2018-08-06
  • 通讯作者: 通信作者:冯磊, Email:fngj2004@163.com
  • 基金资助:
    国家自然科学基金资助项目(81460326);云南省高层次卫生技术人才培养专项经费资助

Distribution of glycosylated hemoglobin and glycosylated serum protein in Yunnan Dai population

  1. Clinical  Laboratory, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi  653100, China
  • Online:2018-07-05 Published:2018-08-06
  • Contact: Corresponding author: Feng Lei, Email:fngj2004@163.com

摘要: 目的  探讨云南傣族人群糖化血红蛋白(HbA1c)和糖化血清蛋白(GSP)在不同性别及年龄中的分布情况。方法  检测860例云南省玉溪市新平彝族傣族自治县戛洒镇傣族(花腰傣)普通人群HbA1c、血红蛋白(Hb)、葡萄糖(FPG)、GSP、白蛋白(albumin, ALB)水平,分析比较各指标不同性别、不同年龄组(41~50岁、51~60岁、61~70岁、>70岁共4组)之间的差异及变化趋势。结果  男性与女性HbA1c、GSP、ALB总体水平差异无统计学意义(P>0.05),而Hb、FPG两性间差异有统计学意义(P<0.05);男性各指标随年龄增长而降低,女性各指标在60岁以前随年龄增长而升高,60岁以后随年龄增长而下降;Pearson相关性检验结果显示,HbA1c与FPG、ALB与GSP在男性和女性中有相关性,且女性中Hb与HbA1c也存在一定相关性。结论  在标准化测定前提下,傣族人群HbA1c和GSP水平不存在性别差异,但不同性别随年龄分布情况不同,男性随年龄增长而降低,女性60岁以前随年龄增长而升高,60岁以后随年龄增长而降低。

关键词: 血红蛋白A,  , 糖基化, 少数民族, 年龄, 性别因素

Abstract: Objective  To investigate the distribution of HbA1c and GSP in the Dai people of Yunnan  of different genders and ages. Methods  The levels of glycosylated hemoglobin (HbA1c), hemoglobin (hemoglobin, Hb), FPGcose (fasting blood glucose, FPG), glycosylated serum protein (GSP) and albumin (albumin, ALB) were detected, analysed and compared in 860 cases of Dai people for the difference and the change trend of each index groups of different genders and  ages (4150 years, 5160 years, 6170 years, >70 years old ). Results  There was no statistical significance  in levels of HbA1c, GSP and ALB between male and female (P>0.05), but the difference  in Hb and FPG between two genders was significant(P<0.05). All the indexes in male decreased with aging, while those of the female kept increasing until 60 years old, then the indexes began to fall. The pearson correlation test showed that there was correlation  in male and female  between HbA1c and FPG,  also ALB and GSP, and there was correlation  in female between Hb and HbA1c. Conclusion  On the premise of standardized determination, there is no gender difference in HbA1c and GSP levels among Dai people. However, their levels may vary in gender, and age,  those of males decreased with age, but females increased until they reached the turning  point60 years old.

Key words: hemoglobin A, , glycosylated;minority , groups;age;sex , factors