维持性血液透析患者发生阻塞性睡眠呼吸暂停低通气综合征与血脂水平关系研究

doi:10.3969/j.issn.1004-583X.2018.07.011

临床荟萃

维持性血液透析患者发生阻塞性睡眠呼吸暂停低通气综合征与血脂水平关系研究

1.上海交通大学附属第六人民医院南院呼吸科，上海 201400；
2.上海交通大学医学院附属第九人民医院奉城分院内分泌科，上海 201415

出版日期:2018-07-05 发布日期:2018-08-06
通讯作者: 通信作者：浦柳美，Email：kzwd13@126.com

Relationship between obstructive sleep apnea and blood lipid level in maintenance hemodialysis patients

1. Department of Respiration, South Branch Hospital, the Sixth People's Hospital Affiliated
to Shanghai Jiaotong University, Shanghai 201400; 2. Department of Endocrinology,
Fengcheng Hospital, the Ninth People's Hospital Affiliated to Shanghai Jiaotong
University School of Medicine, Shanghai 201415

Online:2018-07-05 Published:2018-08-06
Contact: Corresponding author: Pu Liumei, Email：kzwd13@126.com

摘要/Abstract

摘要： 目的探讨维持性血液透析患者发生阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与血脂水平的关系。方法选取2015年7月至2016年7月来我院肾内科治疗的维持性透析患者74例，根据多导睡眠仪监测结果，分为OSAHS组32例和非OSAHS组42例。检测两组呼吸暂停低通气指数（AHI）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC )、载脂蛋白A(ApoA)、载脂蛋白B（ApoB）并进行比较。采用Logistic回归分析维持性血液透析患者合并OSAHS的影响因素。结果 OSAHS组透析时间长于OSAHS组，但两组BMI比较差异无统计学意义（P>0.05）；OSAHS组TC、TG、LDLC、ApoB高于非OSAHS组（P<0.05）；Pearson相关分析发现，AHI与TC、ApoB呈正相关（P＜0.05）；Logistic回归分析显示，ApoB和TC为维持性血液透析患者发生OSAHS的危险因素（P＜0.05）。结论透析时间越长，出现OSAHS的概率越高，且OSAHS与血脂代谢紊乱有相互协同作用。

关键词: 睡眠呼吸暂停, 阻塞性, 肾透析, 血脂异常

Abstract: Objective To investigate the relationship between obstructive sleep apnea hypopnea syndrome(OSAHS) and blood lipid level in maintenance hemodialysis patients.Methods A total of 74 patients with maintenance dialysis in our hospital from July 2015 to July2016 were selected as the research objects, and were divided into OSAHS group (32 cases) and nonOSAHS group (42 cases)in accordance with the monitoring results of the multi sleep monitor.Triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDLC), low density lipoprotein (LDLC), apolipoprotein A (ApoA I) and apolipoprotein B (ApoB) were detected and compared between two groups.Logistic regression was used to analyze the influencing factors of OSAHS in maintenance hemodialysis patients.Results The duration of dialysis in OSAHS group was longer than that in nonOSAHS group, However, there was no significant difference in BMI between two groups (P>0.05); Two groups of patients with blood lipid levels were compared, TC, TG, LDLC, ApoB of OSAHS group were significantly higher than in those of nonOSAHS group (P<0.05); Pearson correlation analysis showed that AHI was positive correlated with TC and ApoB(P＜0.05); Logistic regression analysis showed that ApoB and TC were risk factors for maintenance hemodialysis patients with OSAHS(P<0.05).Conclusion The longer the duration of dialysis, the more risk of OSAHS, and the synergistic effect of OSAHS presented with dyslipidemia.

Key words: sleep , apnea, , obstructive, renal , dialysis, dyslipidemias

浦柳美1，黄国兰2，鲁立文1. 维持性血液透析患者发生阻塞性睡眠呼吸暂停低通气综合征与血脂水平关系研究[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2018.07.011.

Pu Liumei1, Huang Guolan2, Lu Liwen1. Relationship between obstructive sleep apnea and blood lipid level in maintenance hemodialysis patients[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2018.07.011.

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https://huicui.hebmu.edu.cn/CN/Y2018/V33/I7/599

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维持性血液透析患者发生阻塞性睡眠呼吸暂停低通气综合征与血脂水平关系研究

Relationship between obstructive sleep apnea and blood lipid level in maintenance hemodialysis patients

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