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单侧肢体主动运动引发的脑白质激活

  

  1. 1.中国康复研究中心附属北京博爱医院   急诊科,首都医科大学康复医学院,北京  100068;
    2.国家康复辅具研究中心  综合康复科,北京  100176
  • 出版日期:2018-09-05 发布日期:2018-09-26
  • 通讯作者: 通信作者:鲍瑞雪, Email: ruixuebao@gmail.com
  • 基金资助:
    十二五国家支撑计划课题(2015BAI06B02)

Brain activation in the whiter matter during active unilateral limb movement

  1. 1.Department of Emergency, Beijing Boai Hospital,  School of Rehabilitation Medicine,  China Rehabilitation
    Research Center,  Capital Medical University,  Beijing100068,  China;2.Department of Rehabilitation, 
    National Research Center for Rehabilitation Technical Aids,  Beijing 100176,  China
  • Online:2018-09-05 Published:2018-09-26
  • Contact: Corresponding author: Bao Ruixue, Email: ruixuebao@gmail.com

摘要: 目的  研究单侧肢体主动运动时脑白质的激活效应。方法 纳入21例受试者接受功能性磁共振成像。以3T磁共振成像系统采集全脑功能像。采用3种运动方式:右侧踝主动背屈, 右侧踝背屈叠加同步主动肌刺激,右侧踝背屈叠加同步对照区域刺激。运动任务采用组块设计模式。以SPM8软件包分析数据,采用混合效应模型进行组分析,以P<0.01作为阈值检测脑白质激活。结果 3种运动方式均可观察到分布于双侧放射冠区的脑白质激活,以左侧为主。结论 单侧肢体主动运动能够激活对侧脑放射冠区白质。脑白质的激活可能能够直接显示神经传导通路的功能状态。

关键词: 主动运动, 脑白质激活, 磁共振成像

Abstract: Objective  To investigate effects of brain activation in the whiter matter during active unilateral limb movement. Methods  A functional magnetic resonance imaging study was performed  in 21 male subjects in three conditions: active ankle movement on the right side; movement plus concurrent stimulation over the tibialis anterior;  and movement plus concurrent stimulation over a control area. SPM8 was used to analyze data. The threshold was set at a familywise error rate correction P<0.01. Results  All conditions evoked bilateral activation in the corona radiate. The activation was mainly distributed on the left side. Conclusion  Unilateral limb movement can evoke brain activation in the corona radiate on the contralateral side. Such activation may indicate the functional state of neural pathways.

Key words: active movement, white matter activation, magnetic resonance imaging