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摘要： 最新研究发现，生长抑制特异性转录本5（growth arrestspecific transcript 5，GAS5）在多种急、慢性疾病的发生和发展过程中具有重要调控作用。研究显示，GAS5能够调控细胞增殖、凋亡、细胞周期等生命过程，与急性心肌梗死、缺血性脑卒中、高血压等多种疾病发生、发展及治疗密切相关，推测其有望成为疾病精准靶向治疗的新靶标。本文就GAS5在肾脏病中的相关研究进展进行综述。
关键词: 肾疾病, 肾肿瘤, LncRNA GAS5
Abstract: Latest studies have reported that growth arrestspecific transcript 5 plays an important role in multiple acute and chronic diseases. The current studies report that GAS5,which is identified as a potential novel tumor suppressor gene regulating vital events, such as cell proliferation, apoptosis, and cell cycle, is closely related to the acute myocardial infarction, ischemic stroke, and hypertension. It is expected that GAS5 can be a new target for precise targeting therapy. The paper reviews the relationship between GAS5 and kidney diseases.
Key words: kidney diseases； kidney neoplasms, LncRNA GAS5
高少辉，徐金升. LncRNA GAS5与肾脏病发生关系[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2018.10.004.
Gao Shaohui, Xu Jinsheng. LncRNA GAS5 and chronic kidney diseases[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2018.10.004.
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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2018.10.004
https://huicui.hebmu.edu.cn/CN/Y2018/V33/I10/846
