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血浆ghrelin与慢性肾脏病并发症

  

  1. 河北省人民医院 肾内科,河北 石家庄 050051
  • 出版日期:2018-10-05 发布日期:2018-11-12
  • 通讯作者: 通信作者:刘冰,Email :liubingzhuren@126.com
  • 作者简介:刘冰,主任医师、教授、硕士生导师。河北省人民医院医疗副院长,大内科主任,肾内学科主任。任中国医师协会肾脏病分会、中国医院管理协会血液净化分会委员;河北省医师协会肾脏内科医师分会侯任主任委员,河北省医学会肾脏病分会副主任委员、河北省肾脏病及血液净化质控中心副主任。

Serum ghrelin and chronic kidney diseases

  1. Department of Nephrology,  Hebei General Hospital,  Shijiazhuang 050051,  China
  • Online:2018-10-05 Published:2018-11-12
  • Contact: Corresponding author:Liu Bing, Email:liubingzhuren@126.com

摘要: 维持性透析患者的并发症严重威胁其生存质量,其中营养不良、微炎症、血管病变相互联系,增加了透析患者的患病率与病死率。近些年研究的ghrelin具有促进生长激素释放的作用,而且涉及到心血管疾病、炎症的病理生理过程,同时它可以改善患者的营养状态。检测ghrelin的水平可以对维持性透析患者做出较早的干预,对临床辅助诊治有重大意义。现就 ghrelin与慢性肾脏病并发症的相关性研究进展进行综述。

关键词: 肾疾病, 营养不良, 微炎症, 血管病变

Abstract: Complications of patients treated with  maintenance dialysis threaten their quality of life seriously, of which malnutrition,microinflammation and vascular lesion are interrelated,  increasing the morbidity and mortality . Ghrelin can potently stimulate the release of growth hormone, improve the nutritional status of patients and is involved in the pathophysiological process of cardiovascular disease and inflammation. Detection of ghrelin concentrations could make early intervention for maintenance dialysis patients, which is of great significance for clinical auxiliary diagnosis and treatment. This paper reviews the progress on the relationship between ghrelin and chronic kidney disease complications.

Key words: kidney disease, ghrelin; , malnutrition, inflammation; , vascular lesion