关键词: 营养不良, klotho蛋白, 成纤维细胞生长因子23, 腹膜透析

Abstract: Objective  To investigate the relationship between the level of serum klotho protein,  FGF23 and nutritional status of patients with maintenance peritoneal dialysis. Methods  A total of 54 patients with continuous ambulate peritoneal dialysis（CAPD）  treated in our hospital from January 2018 to January 2019 were selected as the study subjects. CAPD patients were divided into three groups according to the Modified Quantitative Subjective Global Assessment (MQsGA).Group A: wellnourished group; Group B: the mild to moderate malnutrition group; Group C: the severe malnutrition group. Serum levels of klotho protein and FGF23 were detected by ELISA. Results  The incidence of CAPD combined with malnutrition in the center was 59.2%,  and the incidence of severe malnutrition was 16.7%. Compared with the wellnourished group,  there were statistically significant differences in the levels of albumin,  creatinine,  hemoglobin,  CRP,  PTH,  BMI,  MAMC,  klotho and FGF23 in the mild to moderate malnutrition group and the severe malnutrition group. There were statistically significant differences in albumin,  creatinine,  hemoglobin,  PTH,  klotho and FGF23 between the severe malnutrition group and the mild to moderate malnutrition group. Correlation analysis showed that  MQsGA score was negatively correlated with the levels of creatinine,  hemoglobin,  albumin and  klotho,  while positively correlated with the levels of CRP,  FGF23  and PTH. Multiple linear regression analysis showed that the levels of klotho and FGF23 were correlated with the nutritional status of peritoneal dialysis. Conclusion  Patients with peritoneal dialysis have a higher incidence of malnutrition. Serum klotho and FGF23 levels are closely related to the nutritional status of patients,  and serum klotho and FGF23 levels are independent risk factors for the nutritional status of peritoneal dialysis patients.

Key words: malnutrition； klotho, fibroblast growth factors 23, peritoneal dialysis