右美托咪定联合丙泊酚和舒芬太尼在电子支气管镜检查中的临床研究

doi:10.3969/j.issn.1004-583X.2019.10.007

临床荟萃

右美托咪定联合丙泊酚和舒芬太尼在电子支气管镜检查中的临床研究

1.河南大学第一附属医院麻醉科，河南开封 475000；2.河南大学淮河医院消化内科, 河南开封 475000；3.河南大学医学院，河南开封 475000

出版日期:2019-10-20 发布日期:2019-12-09
通讯作者: 王莹，Email: hdyfywy@163.com

Clinical study of dexmedetomidine combined with propofol and sufentanil in painless flexible bronchoscopy

1.Department of Anesthesiology, the First Affiliated Hospital of Henan University, Kaifeng 475000, China;
2. Department of Gastroenterology, Huaihe Hospital of Henan University, Kaifeng 475000, China;
3. Henan University School of Medicine, Kaifeng 475000, China

Online:2019-10-20 Published:2019-12-09
Contact: Corresponding author：Wang Ying, Email: hdyfywy@163.com

摘要/Abstract

摘要： 目的研究右美托咪定联合丙泊酚和舒芬太尼的麻醉方法在支气管镜检查中的安全性与有效性，以及在临床中的应用价值。方法将接受支气管镜检查的60例患者随机分为两组：右美托咪定联合丙泊酚和舒芬太尼组（DPS组：n=30，1 μg/kg的右美托咪定静脉泵注10 min，在泵注5 min时静脉注射舒芬太尼0.1 μg/kg）和丙泊酚复合舒芬太尼组（PS组：n=30，0.25 ml/kg的生理盐水静脉泵注10 min，术前5 min静脉注射舒芬太尼0.1 μg/kg），使用丙泊酚行麻醉诱导和维持。结果 DPS组的MOAA/S评分在T2、T3高于PS组（P＜0.05），在T4、T5、T6则低于PS组（P＜0.05）；DPS组的Ramsay评分在T1时高于PS组（P＜0.05）；PS组的HR在T5、T6高于DPS组（P＜0.05），其SpO2在T3至T5低于DPS组（P＜0.05）；DPS组的DBP和SBP在T5、T6低于PS组（P＜0.05）；DPS组丙泊酚消耗量低于PS组（P＜0.05），而患者的麻醉苏醒时间较PS组长（P＜0.05）；DPS组的呛咳发生情况优于PS组（P＜0.05），但低血压的发生高于PS组（P＜0.05）；DPS组的气管镜医师满意度评分高于PS组。结论右美托咪定联合丙泊酚和舒芬太尼的麻醉方法在无痛气管镜检查中是安全、有效的，能够为患者提供稳定的血流动力学和较深的镇静水平。

关键词: 右美托咪定, 丙泊酚 , 支气管镜检查 , 血液动力学现象 , 咳嗽

Abstract: Objective To study the safety and effectiveness of dexmedetomidine combined with propofol and sufentanil anesthesia in bronchoscopy and their clinical value. Methods Sixty patients who accepted bronchoscopic examination were randomly divided into two groups: DPS group（Dexmedetomidine combined with propofol and sufentanil group, n=30, 1 μg/kg dexmedetomidine intravenous infusion for 10 minutes and intravenous infusion of 0.1 μg/kg sufentanil for 5 minutes.) and PS group (Propofol combined with sufentanil, n=30, 0.25 ml/kg saline was infused intravenously for 10 minutes and intravenous infusion of 0.1 μg/kg sufentanil for 5 minutes before operation), then propofol was used to induce and maintain anesthesia. Results The MOAA/S score of DPS group was higher than that of PS group at T2 and T3 time points (P<0.05), and it was lower than that of PS group at T4, T5 and T6 time points (P<0.05); Ramsay score of DPS group was higher than that of PS group at T1 time point (P<0.05); HR of PS group was higher than that of DPS group at T5 and T6 time points (P<0.05). At T3, T4 and T5 time points, SpO2 was lower than DPS group (P<0.05); DBP and SBP of DPS group were lower than those of PS group at T5 and T6 time points (P<0.05); propofol consumption of DPS group was lower than that of PS group (P<0.05), and anesthesia recovery time of DPS group was longer than PS group (P<0.05). The incidence of cough in DPS group was less than that in PS group (P<0.05), but the incidence of hypotension was higher than that in PS group (P<0.05). The satisfaction score of physicians of DPS group was higher than that in PS group. Conclusion The anesthesia method of dexmedetomidine combined with propofol and sufentanil is safe and effective in painless flexible bronchoscopy, which can provide stable hemodynamics and deep sedation for patients.

Key words: dexmedetomidine, propofol, bronchoscopy, hemodynamic phenomina, cough

韩锋1,田欣欣2，宋俊杰1，陈慧娜1，王莹3. 右美托咪定联合丙泊酚和舒芬太尼在电子支气管镜检查中的临床研究[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2019.10.007.

Han Feng1, Tian Xinxin2, Song Junjie1, Chen Huina1, Wang Ying3. Clinical study of dexmedetomidine combined with propofol and sufentanil in painless flexible bronchoscopy[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2019.10.007.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2019.10.007

https://huicui.hebmu.edu.cn/CN/Y2019/V34/I10/898

[1]	李远鹏, 陈亮, 刘俊安, 李天林. 合并过敏性鼻炎的亚急性咳嗽患者临床分析[J]. 临床荟萃, 2023, 38(10): 904-906.
[2]	郑紫磊, 杨延江, 李海英. 右美托咪定对腹股沟嵌顿性疝致肠缺血-再灌注损伤手术老年患者肝肾功能的保护及影响[J]. 临床荟萃, 2021, 36(8): 735-738.
[3]	韩锋1，王莹1，田欣欣2，宋俊杰1，陈慧娜1. 不同麻醉药物在支气管镜检查中的应用[J]. 临床荟萃, 2020, 35(3): 268-272.
[4]	袁博云, 刘欣, 袁雅冬. 2018年呼吸系统疾病研究部分进展[J]. 临床荟萃, 2019, 34(1): 49-55.
[5]	徐明鹏1，李莉华1，黎雨1，梁毅林2，甘罗曼3，柳广南1. 长疗程抗生素联合雾化吸入在良性气管狭窄呼吸内镜治疗中的作用[J]. 临床荟萃, 2017, 32(4): 327-330,335.
[6]	周金花1，高冉2，贾建军1，刘瑞娟1. 无痛下经支气管镜针吸活检在纵隔及肺门占位性病变诊断中的价值[J]. 临床荟萃, 2017, 32(11): 986-988.
[7]	潘文森，于婧，袁雅冬. 气道内超声引导鞘技术对于良性周边型肺部病变的诊断[J]. 临床荟萃, 2016, 31(8): 882-885.
[8]	潘文森，袁雅冬. 周边型肺部病变的内镜诊断[J]. 临床荟萃, 2016, 31(11): 1178-1183.
[9]	段争，袁雅冬. 纵隔疾病的诊断进展[J]. 临床荟萃, 2016, 31(11): 1174-1177.
[10]	王洪武. 中央型气道新的八分区方法和恶性气道肿瘤的治疗策略[J]. 临床荟萃, 2016, 31(11): 1167-1169.
[11]	金发光. 支气管镜新技术在肺癌早期诊断中的应用[J]. 临床荟萃, 2016, 31(11): 1161-1166.
[12]	李艳萍. 支气管镜下取出气管中下段水蛭1例[J]. 临床荟萃, 2015, 30(8): 950-0.
[13]	陈晓丽. 纤维支气管镜检查对结核疑难病例诊断和治疗价值[J]. 临床荟萃, 2015, 30(10): 1173-1175.
[14]	李亚洁;陈凯. 高阳性率经支气管淋巴结针吸活检224例分析[J]. 临床荟萃, 2015, 30(10): 1159-1162.
[15]	宫小薇;段争;袁雅冬;于婧;刘欣;张爱彦. 超声支气管镜引导下经支气管针吸活检在诊断肺部及纵隔病变中的应用[J]. 临床荟萃, 2014, 29(12): 1362-1.36414e+007.

右美托咪定联合丙泊酚和舒芬太尼在电子支气管镜检查中的临床研究

Clinical study of dexmedetomidine combined with propofol and sufentanil in painless flexible bronchoscopy

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价