关键词: 抗中性粒细胞胞浆抗体相关性血管炎, 血栓栓塞, 危险因素

Abstract: Objective  To analyze the clinical features and related risk factors of  antineutrophil cytoplasmic antibody  associated vasculitis (AAV) complicated with thromboembolism events.Methods  A total of 177 patients diagnosed as AAV from January 2013 to December 2018 were collected, of which 28 patientswith ATE and VTE and 149 patients. Logistic regression analysis was used to explore the risk factors of AAV patients complicated with thromboembolism.Results  In the embolization group，23  patients(82.1%) were in AAV active stage, five patients(17.9%) were in remission stage, and 50.0% of the patients suffered from the disease two months after the diagnosis. Compared with nonembolization group, the acute infection rate, BVAS score, serum creatinin and ESR level in embolization group were higher. However, the blood platelet count and C3 level were lower (P<0.05). Multivariate logistic regression analysis showed that complicated acute infection, the level of ESR and C3 were independent risk factors for AAV  complicated with thromboembolism.Conclusion  Patients with AAV have a higher risk of thromboembolism during the active period, especially two months after the diagnosis of the disease. AAV  patients with acute infection, increased ESR and decreased C3 may be more susceptible to thromboembolism.

Key words: antineutrophil cytoplasmic antibodyassociated , vasculitis; , thromboembolism, risk factors