LDL-C/HDL-C在2型糖尿病合并冠心病中的预测价值

doi:10.3969/j.issn.1004-583X.2020.04.011

临床荟萃

LDL-C/HDL-C在2型糖尿病合并冠心病中的预测价值

大连市中心医院内分泌科, 辽宁大连 116011

出版日期:2020-04-20 发布日期:2020-04-16
通讯作者: 高政南，Email: gao2008@163.com

The predictive value of LDLC/HDLC in type 2 diabetes mellitus with coronary heart disease

Department of Endocrinology, Dalian Municipal Central Hospital, Dalian 116011, China

Online:2020-04-20 Published:2020-04-16
Contact: Corresponding author: Gao Zhengnan, Email: gao2008@163.com

摘要/Abstract

摘要： 目的探讨2型糖尿病合并冠心病患者血脂与冠状动脉粥样硬化程度的相关性。方法选取2型糖尿病患者286例,根据冠状动脉造影情况分为2型糖尿病合并冠状动脉狭窄<50％（A组）；2型糖尿病并冠状动脉狭窄≥50％（B组）。比较各组间一般资料及生化等指标。结果两组糖尿病病程、糖化血红蛋白、低密度脂蛋白胆固醇（LDLC）、高密度脂蛋白胆固醇（HDLC）、LDLC/HDLC比较差异有统计学意义；多元Logistic回归分析显示：LDLC/HDLC是2型糖尿病患者发生冠状动脉粥样硬化的独立危险因素；ROC曲线结果显示：LDLC/HDLC最佳临界点为2.53时敏感度为77.6%，特异度为82.3%。结论 LDLC/HDLC在预测2型糖尿病患者发生冠状动脉病变优于单纯LDLC和HDLC。

关键词: 糖尿病, 2型, 冠状动脉病变, 胆固醇, LDL, 胆固醇, HDL

Abstract: Objective To investigate the correlation between blood lipids and the degree of coronary atherosclerosis in patients with type 2 diabetes and coronary heart disease. Methods According to the status of coronary angiography, a total of 286 patients with type 2 diabetes were divided into two groups: type 2 diabetes with coronary artery stenosis <50%(Group A), and type 2 diabetes with coronary artery stenosis≥50% (Group B). General information and biochemical indicators between two groups were compared. Results There was significant difference between two groups in the course of diabetes, hemoglobin A1c (HbA1c), lowdensity lipoprotein cholesterol(LDLC), highdensity lipoprotein cholesterol (HDLC), and LDLC/HDLC（P＜0.05). Logistic multivariate regression analysis showed that: LDLC/HDLC was an independent risk factor for coronary atherosclerosis in patients with type 2 diabetes. The ROC curve results showed that the optimal critical point of LDLC/HDLC was 2.53, at this time the sensitivity was 77.6% and the specificity was 82.3%.Conclusion LDLC/HDLC is better than LDLC and HDLC in predicting coronary artery disease in patients with type 2 diabetes.

Key words: diabetes mellitus；type 2； coronary artery disease； cholesterol, LDL, cholesterol, HDL

刘明明, 李欣宇. LDL-C/HDL-C在2型糖尿病合并冠心病中的预测价值[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2020.04.011.

Liu Mingming, Li Xinyu. The predictive value of LDLC/HDLC in type 2 diabetes mellitus with coronary heart disease[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2020.04.011.

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https://huicui.hebmu.edu.cn/CN/Y2020/V35/I4/340

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LDL-C/HDL-C在2型糖尿病合并冠心病中的预测价值

The predictive value of LDLC/HDLC in type 2 diabetes mellitus with coronary heart disease

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