血清25-(OH)D水平与儿童矮身材的关系

doi:10.3969/j.issn.1004-583X.2021.04.013

摘要/Abstract

摘要：

目的探讨血清25-(OH)水平与儿童矮身材的关系。方法回顾性收集我院儿童内分泌专科门诊就诊并诊断为矮身材172例(男94例,女78例,8.50±3.18岁),根据病因将其分为生长激素缺乏(GHD)组78例及特发性矮小(ISS)组94例;选择同期在我院健康体检的儿童175例作对照(男84例,女91例,7.65±1.19岁),分析血清25-(OH)D水平与儿童矮身材的关系。结果 (1)GHD组及ISS与对照组比较, 年龄、身高、体质量差异均有统计学意义(P<0.05),GHD组血清25-(OH)D水平明显低于ISS组及对照组(P<0.01);ISS组不同性别儿童血清25-(OH)D水平比较差异有统计学意义(P<0.05),且男性高于女性(P=0.011);(2)维生素D缺乏比例在GHD组(30.76%, 24/78例)高于ISS组(6.38%, 6/94例)(χ²=17.604,P<0.01)。结论矮身材儿童血清25-(OH)D水平降低,GHD患儿更明显。

关键词: 矮身材, 25-(OH)D, 生长激素缺乏症, 特发性矮小

Abstract:

Objective The purpose of this study is to investigate the relations between serum 25-(OH)D level and short stature in children. Methods One hundred and seventy two patients who visited the pediatric endocrine clinic of the hospital and were diagnosed to have short stature (94 males, 78 females, 8.50±3.18 years old) were retrospectively collected, 78 cases were included in the growth hormone deficiency (GHD) group, 94 cases were included in the idiopathic short stature (ISS) group according to the causes. A total of 175 healthy children (84 males and 91 females, 7.65±1.19 years old) undergoing physical examination in the hospital during the same period were selected to be controlled. The relations between serum 25-(OH) D level and short stature of children were analyzed. Results (1)The differences in the age, height and body mass of children in GHD group, ISS group and control group were statistically significant (P<0.05), the serum 25-(OH)D level in GHD group was significantly lower than that in ISS group and control group(P<0.01).The difference in serum 25-(OH)D level between different genders in ISS group (P<0.05) was a statistically significant, and serum 25-(OH)D level in male children was higher than that in female children(P=0.011).(2)The proportion of vitamin D deficiency in GHD group (30.76%, 24/78) was higher than that in ISS group (6.38%,6/94)(χ²=17.604, P<0.01). Conclusion The decreased serum 25-(OH)D level is more obvious in children with short stature, especially in children with GHD among them.

Key words: short stature, 25-hydroxy vitamin D, growth hormone deficiency, idiopathic short stature

中图分类号:

R725

邵娜, 王硕, 栗瑶, 罗雪梅, 谭传梅. 血清25-(OH)D水平与儿童矮身材的关系[J]. 临床荟萃, 2021, 36(4): 353-356.

Shao Na, Wang Shuo, Li Yao, Luo Xuemei, Tan Chuanmei. Relations between serum 25-(OH)D level and short stature in children[J]. Clinical Focus, 2021, 36(4): 353-356.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.04.013

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I4/353

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参考文献 25

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组别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
对照组	175	7.65±1.19	127.91±10.23	26.79±6.93	16.17±2.42	25.56±4.10
GHD	78	9.25±2.69	121.78±15.04	24.98±9.49	16.38±2.92	22.85±3.93
ISS	94	7.89±3.43	116.76±19.05	23.49±10.39	16.66±3.36	25.43±3.99
F值		12.614	19.586	4.694	0.952	13.231
P值		0.00	<0.05	0.01	>0.05	0.00

组别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
对照组	175	7.65±1.19	127.91±10.23	26.79±6.93	16.17±2.42	25.56±4.10
GHD	78	9.25±2.69	121.78±15.04	24.98±9.49	16.38±2.92	22.85±3.93
ISS	94	7.89±3.43	116.76±19.05	23.49±10.39	16.66±3.36	25.43±3.99
F值		12.614	19.586	4.694	0.952	13.231
P值		0.00	<0.05	0.01	>0.05	0.00

性别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
男	46	9.47±4.08	121.16±15.87	23.58±8.20	15.72±2.23	23.43±4.08
女	32	8.88±2.09	122.69±13.97	26.99±10.91	17.31±3.51	22.01±3.59
t值		1.017	-1.498	-1.576	-2.442	1.582
P值		0.002	0.178	0.084	0.001	0.572

性别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
男	46	9.47±4.08	121.16±15.87	23.58±8.20	15.72±2.23	23.43±4.08
女	32	8.88±2.09	122.69±13.97	26.99±10.91	17.31±3.51	22.01±3.59
t值		1.017	-1.498	-1.576	-2.442	1.582
P值		0.002	0.178	0.084	0.001	0.572

性别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
男	48	8.01±3.82	117.09±20.44	23.56±10.48	16.50±2.96	25.53±4.70
女	46	7.76±3.00	116.42±17.70	23.42±10.41	16.83±3.77	25.32±3.13
t值		0.353	0.169	0.066	-0.485	0.251
P值		0.006	0.218	0.998	0.058	0.011