中老年焦虑障碍与胰岛素抵抗相关性

doi:10.3969/j.issn.1004-583X.2021.08.007

摘要/Abstract

摘要：

目的探讨中老年焦虑障碍与胰岛素抵抗(insulin resistance, IR)的相关性。方法随机选取2019年1月-2019年12月收治的50~80岁初次诊断的焦虑障碍患者159例为研究组,同期随机选取健康体检者150例为对照组, 收集两组的人口学资料,采用汉密尔顿焦虑量表(HAMA)进行评分。检测并比较两组空腹胰岛素(FINS)、空腹血糖 (FPG)。采用稳态模式评估法公式计算胰岛素抵抗指数(HOMA-IR)。采用Pearson相关分析,探讨中老年焦虑障碍与IR的关系。结果研究组FINS、HOMA-IR、HAMA评分明显高于对照组(均P<0.05);Pearson相关分析发现,HOMA-IR与HAMA评分无明显相关性(r=-0.049,P=0.536)。结论中老年焦虑障碍患者IR较相同年龄健康人群增加,但未发现IR与焦虑严重程度有相关性。

关键词: 精神障碍, 胰岛素, 血糖

Abstract:

Objective To explore the correlation between anxiety disorder and insulin resistance(IR) in middle-aged and elderly. Methods A total of 159 patients aged 50 to 80 years who were first diagnosed with anxiety disorder were randomly selected as the study group from January 2019 to December 2019. 150 healthy subjects were randomly selected as the control group at the same time. Demographic data of two groups were collected, and the Hamilton Anxiety Scale(HAMA) was used for grading.Fasting insulin(FINS) and fasting blood glucose(FPG) were measured and compared between groups. Homeostatic model assessment of insulin resistance was used to calculate insulin resistance index(HOMA-IR).Pearson correlation analysis was used to explore relationship between anxiety disorder and IR in middle-aged and elderly.Results FINS, HOMA-IR, HAMA score were significantly higher in study group than in control group (all P<0.05). Pearson correlation analysis showed that HOMA-IR had no significant correlation with HAMA score(r=-0.049, P=0.536).Conclusion The level of IR in middle-aged and elderly with anxiety disorder is higher than in healthy people of the same age, but there is no correlation between IR and the severity of anxiety.

Key words: mental disorders, insulin, blood glucose

中图分类号:

张如阳, 冯倩. 中老年焦虑障碍与胰岛素抵抗相关性[J]. 临床荟萃, 2021, 36(8): 708-712.

Zhang Ruyang, Feng Qian. Association between anxiety disorder and insulin resistance in middle-aged and elderly[J]. Clinical Focus, 2021, 36(8): 708-712.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.08.007

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I8/708

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参考文献 34

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组别	例数	性别[例(%)]			年龄 (岁)		体质量 (kg)		身高 (m)		BMI (kg/m²)
组别	例数	男	女		年龄 (岁)		体质量 (kg)		身高 (m)		BMI (kg/m²)
研究组	159	70(44.0)	89(56.0)		60.48±7.01		60.48±7.01		1.63±0.07		22.72±1.71
对照组	150	70(46.7)	80(53.3)		59.86±7.55		60.95±7.05		1.64±0.06		22.64±1.77
统计值		χ²=0.217			t=0.671		t=-0.586		t=-1.227		t=0.390
P值		0.649			0.503		0.558		0.221		0.697
组别	例数	TC (mmol/L)		TG (mmol/L)		LDL-C (mmol/L)		HDL-C (mmol/L)		MMSE评分 (分)		HAMD评分 (分)
研究组	159	2.60±0.83		3.70±1.36		2.88±0.64		1.25±0.24		29.04±1.10		1.00±0.71
对照组	150	2.61±0.85		3.70±1.38		2.85±0.63		1.27±0.26		28.96±1.32		0.99±0.72
统计值		t=-0.049		t=0.001		t=0.414		t=-0.468		t=0.566		t=0.163
P值		0.961		0.999		0.679		0.640		0.572		0.870

组别	例数	性别[例(%)]			年龄 (岁)		体质量 (kg)		身高 (m)		BMI (kg/m²)
组别	例数	男	女		年龄 (岁)		体质量 (kg)		身高 (m)		BMI (kg/m²)
研究组	159	70(44.0)	89(56.0)		60.48±7.01		60.48±7.01		1.63±0.07		22.72±1.71
对照组	150	70(46.7)	80(53.3)		59.86±7.55		60.95±7.05		1.64±0.06		22.64±1.77
统计值		χ²=0.217			t=0.671		t=-0.586		t=-1.227		t=0.390
P值		0.649			0.503		0.558		0.221		0.697
组别	例数	TC (mmol/L)		TG (mmol/L)		LDL-C (mmol/L)		HDL-C (mmol/L)		MMSE评分 (分)		HAMD评分 (分)
研究组	159	2.60±0.83		3.70±1.36		2.88±0.64		1.25±0.24		29.04±1.10		1.00±0.71
对照组	150	2.61±0.85		3.70±1.38		2.85±0.63		1.27±0.26		28.96±1.32		0.99±0.72
统计值		t=-0.049		t=0.001		t=0.414		t=-0.468		t=0.566		t=0.163
P值		0.961		0.999		0.679		0.640		0.572		0.870

组别	例数	FPG (mmol/L)	FINS (mmol/L)	HOMA-IR	HAMA 评分
研究组	159	5.40±0.67	7.40±2.01	1.78±0.49	19.67±3.01
对照组	150	5.34±0.60	6.31±1.71	1.50±0.41	1.00±0.29
t值		0.720	2.779	2.894	73.670
P值		0.472	0.006	0.004	0.001

组别	例数	FPG (mmol/L)	FINS (mmol/L)	HOMA-IR	HAMA 评分
研究组	159	5.40±0.67	7.40±2.01	1.78±0.49	19.67±3.01
对照组	150	5.34±0.60	6.31±1.71	1.50±0.41	1.00±0.29
t值		0.720	2.779	2.894	73.670
P值		0.472	0.006	0.004	0.001