建立规律月经周期的青春期McCune-Albright综合征1例及文献复习

doi:10.3969/j.issn.1004-583X.2022.05.011

临床荟萃 ›› 2022, Vol. 37 ›› Issue (5): 447-450.doi: 10.3969/j.issn.1004-583X.2022.05.011

建立规律月经周期的青春期McCune-Albright综合征1例及文献复习

廉怡华, 皮亚雷, 张亚男, 张会丰()

河北医科大学第二医院儿科,河北石家庄 050000

收稿日期:2021-08-23 出版日期:2022-05-20 发布日期:2022-06-22
通讯作者: 张会丰 E-mail:13333015983@163.com

McCune-Albright syndrome in adolescence with regular menstrual cycle: A case report and literature review

Lian Yihua, Pi Yalei, Zhang Yanan, Zhang Huifeng()

Department of Pediatrics, The Second Hospital of Hebei Medical University,Shijiazhuang 050000, China

Received:2021-08-23 Online:2022-05-20 Published:2022-06-22
Contact: Zhang Huifeng E-mail:13333015983@163.com

摘要/Abstract

摘要：

目的分析治疗外周性性早熟各类药物的差异,提高McCune-Albright综合征(MAS)的治疗水平。方法本文通过回顾1例MAS患儿从幼儿期阴道出血直至青春期建立正常月经周期的诊疗经过,并复习相关文献,分析治疗外周性性早熟的各类药物的利弊,为儿童内分泌专科医生提供诊疗及预后参考。结果来曲唑从根源上减少雌激素产生,且治疗期间安全性相对较好。结论来曲唑似乎更适用于治疗MAS患儿的外周性性早熟,但用药过程中需注意系统的随访评估。

关键词: 纤维发育不良,多骨, 月经周期, 他莫昔芬, 达那唑, 来曲唑

Abstract:

Objective To analyze the differences of various drugs in treatment of peripheral precocious puberty, and improve the therapeutic level to McCune-Albright syndrome (MAS). Methods In this article, the data of a MAS child from pediatric vaginal bleeding in infancy to regular menstrual cycle in adolescence and the relevant literatures were retrospectively review, the pros and cons of various drugs in treatment of peripheral precocious puberty were analyzed, aiming to provide reference for pediatric endocrinologists. Results Letrozole was relatively safe by reducing endogenous estrogen during treatment. Conclusion Letrozole seems to be more suitable for the treatment of peripheral precocious puberty in MAS children, but follow-up assessments are essential.

Key words: fibrous dysplasia,polyostotic, menstrual cycle, tamoxifen, danazol, letrozole

中图分类号:

R681

廉怡华, 皮亚雷, 张亚男, 张会丰. 建立规律月经周期的青春期McCune-Albright综合征1例及文献复习[J]. 临床荟萃, 2022, 37(5): 447-450.

Lian Yihua, Pi Yalei, Zhang Yanan, Zhang Huifeng. McCune-Albright syndrome in adolescence with regular menstrual cycle: A case report and literature review[J]. Clinical Focus, 2022, 37(5): 447-450.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2022.05.011

https://huicui.hebmu.edu.cn/CN/Y2022/V37/I5/447

图/表 1

参考文献 19

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时间	年龄 (岁)	左侧卵巢 (mm)	左侧卵巢特征	右侧卵巢 (mm)	右侧卵巢特征	子宫 (mm)	内膜 (mm)
2011-6-11	3.25	未见明显异常	-	48×42囊性团块	-	26×16	6
2011-9-14	3.5	14.9×18.7×7.8	-	34.9×39.5×37.3	23、18 mm暗区	26.6×27.4×17.6	4
2013-6-13	5.25	14.9×15.7×14.5	6.1 mm暗区	15.8×16.1×10.7	-	27.5×28×22.1	3.4
2014-3-17	6	27.7×17.8×16.6	-	24.9×21×16.8	18.1 mm暗区	25.7×32.1×20.5	2.7
2014-4-28	6.1	22.4×15.7×15.8	9.2 mm暗区	16.8×20.5×13	8.1、7.7 mm暗区	25.7×33.2×19.1	1.3
2016-7-8	8.3	26.2×13.4	-	子宫右侧探及73.6×64.3×51.1液性包块,包块内见多条强回声分隔,包块周围似可探及部分卵巢回声		28.7×28×21.3	3.7
2018-4-23	10.1	23.2×16.5×10.2	15.4×17.3×3.8 mm暗区	34.3×23.5×29	13.1、10.7、32.2 mm暗区	24.6×22.1×19.2	2.3
2018-10-1	10.5	31.6×23.1	2/3暗区	40.3×28.7	2/3暗区	26.9×28×28.6	3.4

时间	年龄 (岁)	左侧卵巢 (mm)	左侧卵巢特征	右侧卵巢 (mm)	右侧卵巢特征	子宫 (mm)	内膜 (mm)
2011-6-11	3.25	未见明显异常	-	48×42囊性团块	-	26×16	6
2011-9-14	3.5	14.9×18.7×7.8	-	34.9×39.5×37.3	23、18 mm暗区	26.6×27.4×17.6	4
2013-6-13	5.25	14.9×15.7×14.5	6.1 mm暗区	15.8×16.1×10.7	-	27.5×28×22.1	3.4
2014-3-17	6	27.7×17.8×16.6	-	24.9×21×16.8	18.1 mm暗区	25.7×32.1×20.5	2.7
2014-4-28	6.1	22.4×15.7×15.8	9.2 mm暗区	16.8×20.5×13	8.1、7.7 mm暗区	25.7×33.2×19.1	1.3
2016-7-8	8.3	26.2×13.4	-	子宫右侧探及73.6×64.3×51.1液性包块,包块内见多条强回声分隔,包块周围似可探及部分卵巢回声		28.7×28×21.3	3.7
2018-4-23	10.1	23.2×16.5×10.2	15.4×17.3×3.8 mm暗区	34.3×23.5×29	13.1、10.7、32.2 mm暗区	24.6×22.1×19.2	2.3
2018-10-1	10.5	31.6×23.1	2/3暗区	40.3×28.7	2/3暗区	26.9×28×28.6	3.4

建立规律月经周期的青春期McCune-Albright综合征1例及文献复习

McCune-Albright syndrome in adolescence with regular menstrual cycle: A case report and literature review

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